The Middle East Respiratory Syndrome—How Worried Should We Be?

ABSTRACT Ten years after the severe acute respiratory syndrome epidemic, a second coronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV), has been identified as the cause of a highly lethal pneumonia in patients in the Middle East and in travelers from this region. Over the past 9 ...

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Autor principal:	Stanley Perlman
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0f3c962ed64146528b2cbfe957560c9b
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spelling	oai:doaj.org-article:0f3c962ed64146528b2cbfe957560c9b2021-11-15T15:43:10ZThe Middle East Respiratory Syndrome—How Worried Should We Be?10.1128/mBio.00531-132150-7511https://doaj.org/article/0f3c962ed64146528b2cbfe957560c9b2013-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00531-13https://doaj.org/toc/2150-7511ABSTRACT Ten years after the severe acute respiratory syndrome epidemic, a second coronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV), has been identified as the cause of a highly lethal pneumonia in patients in the Middle East and in travelers from this region. Over the past 9 months, since the virus was first isolated, much has been learned about the biology of the virus. It is now clear that MERS-CoV is transmissible from person to person, and its close relationship with several bat coronaviruses suggests that these animals may be the ultimate source of the infection. However, many key issues need to be addressed, including identification of the proximate, presumably zoonotic, source of the infection, the prevalence of the infection in human populations, details regarding clinical and pathological features of the human infection, the establishment of a small rodent model for the infection, and the virological and immune basis for the severe disease observed in most patients. Most importantly, we do not know whether a MERS-CoV epidemic is likely or not. Infection with the virus has so far resulted in only 91 cases and 46 deaths (as of 29 July 2013), but it is nonetheless setting off alarm bells among public health officials, including Margaret Chan, Director-General of the World Health Organization, who called MERS-CoV “a threat to the entire world.” This article reviews some of the progress that has been made and discusses some of the questions that need to be answered.Stanley PerlmanAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 4 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Stanley Perlman The Middle East Respiratory Syndrome—How Worried Should We Be?
description	ABSTRACT Ten years after the severe acute respiratory syndrome epidemic, a second coronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV), has been identified as the cause of a highly lethal pneumonia in patients in the Middle East and in travelers from this region. Over the past 9 months, since the virus was first isolated, much has been learned about the biology of the virus. It is now clear that MERS-CoV is transmissible from person to person, and its close relationship with several bat coronaviruses suggests that these animals may be the ultimate source of the infection. However, many key issues need to be addressed, including identification of the proximate, presumably zoonotic, source of the infection, the prevalence of the infection in human populations, details regarding clinical and pathological features of the human infection, the establishment of a small rodent model for the infection, and the virological and immune basis for the severe disease observed in most patients. Most importantly, we do not know whether a MERS-CoV epidemic is likely or not. Infection with the virus has so far resulted in only 91 cases and 46 deaths (as of 29 July 2013), but it is nonetheless setting off alarm bells among public health officials, including Margaret Chan, Director-General of the World Health Organization, who called MERS-CoV “a threat to the entire world.” This article reviews some of the progress that has been made and discusses some of the questions that need to be answered.
format	article
author	Stanley Perlman
author_facet	Stanley Perlman
author_sort	Stanley Perlman
title	The Middle East Respiratory Syndrome—How Worried Should We Be?
title_short	The Middle East Respiratory Syndrome—How Worried Should We Be?
title_full	The Middle East Respiratory Syndrome—How Worried Should We Be?
title_fullStr	The Middle East Respiratory Syndrome—How Worried Should We Be?
title_full_unstemmed	The Middle East Respiratory Syndrome—How Worried Should We Be?
title_sort	middle east respiratory syndrome—how worried should we be?
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/0f3c962ed64146528b2cbfe957560c9b
work_keys_str_mv	AT stanleyperlman themiddleeastrespiratorysyndromehowworriedshouldwebe AT stanleyperlman middleeastrespiratorysyndromehowworriedshouldwebe
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The Middle East Respiratory Syndrome—How Worried Should We Be?

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