Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model

Abstract High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure – intraocular pressure) may be as important as in...

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Autores principales:	Anna K. van Koeverden, Zheng He, Christine T. O. Nguyen, Algis J. Vingrys, Bang V. Bui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f3d58fbb93f41b38c1fb16a30316add
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spelling	oai:doaj.org-article:0f3d58fbb93f41b38c1fb16a30316add2021-12-02T16:08:26ZSystemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model10.1038/s41598-018-25264-42045-2322https://doaj.org/article/0f3d58fbb93f41b38c1fb16a30316add2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25264-4https://doaj.org/toc/2045-2322Abstract High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure – intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion pressure, ultimately leading to poor retinal and optic nerve head blood supply. In this study we showed the presence of increased wall:lumen ratio and wall area of the ophthalmic artery in rats with chronic hypertension in addition to failure of retinal autoregulation in response to acute modification of ocular perfusion pressure. Subsequently we found that in spite of dramatically increasing ocular perfusion pressure, chronic systemic hypertension failed to protect retinal structure and function from a rodent model of glaucoma.Anna K. van KoeverdenZheng HeChristine T. O. NguyenAlgis J. VingrysBang V. BuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna K. van Koeverden Zheng He Christine T. O. Nguyen Algis J. Vingrys Bang V. Bui Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
description	Abstract High intraocular pressure is the most well documented glaucoma risk factor; however many patients develop and/or show progression of glaucoma in its absence. It is now thought that in some instances, ocular perfusion pressure (blood pressure – intraocular pressure) may be as important as intraocular pressure alone. Thus, systemic hypertension would be protective against glaucoma. Epidemiological studies, however, are inconclusive. One theory of why hypertension may not protect against elevated intraocular pressure in spite of increasing ocular perfusion pressure is that with time, morphological changes to the vasculature and autoregulatory failure outweigh the benefits of improved perfusion pressure, ultimately leading to poor retinal and optic nerve head blood supply. In this study we showed the presence of increased wall:lumen ratio and wall area of the ophthalmic artery in rats with chronic hypertension in addition to failure of retinal autoregulation in response to acute modification of ocular perfusion pressure. Subsequently we found that in spite of dramatically increasing ocular perfusion pressure, chronic systemic hypertension failed to protect retinal structure and function from a rodent model of glaucoma.
format	article
author	Anna K. van Koeverden Zheng He Christine T. O. Nguyen Algis J. Vingrys Bang V. Bui
author_facet	Anna K. van Koeverden Zheng He Christine T. O. Nguyen Algis J. Vingrys Bang V. Bui
author_sort	Anna K. van Koeverden
title	Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
title_short	Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
title_full	Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
title_fullStr	Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
title_full_unstemmed	Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
title_sort	systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0f3d58fbb93f41b38c1fb16a30316add
work_keys_str_mv	AT annakvankoeverden systemichypertensionisnotprotectiveagainstchronicintraocularpressureelevationinarodentmodel AT zhenghe systemichypertensionisnotprotectiveagainstchronicintraocularpressureelevationinarodentmodel AT christinetonguyen systemichypertensionisnotprotectiveagainstchronicintraocularpressureelevationinarodentmodel AT algisjvingrys systemichypertensionisnotprotectiveagainstchronicintraocularpressureelevationinarodentmodel AT bangvbui systemichypertensionisnotprotectiveagainstchronicintraocularpressureelevationinarodentmodel
_version_	1718384453544312832

Systemic hypertension is not protective against chronic intraocular pressure elevation in a rodent model

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