Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL

Glioblastoma (GBM) cells are often characterized by the presence of the IDH1 R132H mutation and high expression of anti-apoptotic proteins. Here, the authors show that the inhibition of Bcl-xL is synthetically lethal in IDH1-mutated GBM models and that this effect is mediated by the oncometabolite,...

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Autores principales:	Georg Karpel-Massler, Chiaki Tsuge Ishida, Elena Bianchetti, Yiru Zhang, Chang Shu, Takashi Tsujiuchi, Matei A. Banu, Franklin Garcia, Kevin A. Roth, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f3f4c1834e24518860d56a1a35c45d4
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spelling	oai:doaj.org-article:0f3f4c1834e24518860d56a1a35c45d42021-12-02T14:42:33ZInduction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL10.1038/s41467-017-00984-92041-1723https://doaj.org/article/0f3f4c1834e24518860d56a1a35c45d42017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00984-9https://doaj.org/toc/2041-1723Glioblastoma (GBM) cells are often characterized by the presence of the IDH1 R132H mutation and high expression of anti-apoptotic proteins. Here, the authors show that the inhibition of Bcl-xL is synthetically lethal in IDH1-mutated GBM models and that this effect is mediated by the oncometabolite, 2-HG, which reduces Mcl-1 protein levels.Georg Karpel-MasslerChiaki Tsuge IshidaElena BianchettiYiru ZhangChang ShuTakashi TsujiuchiMatei A. BanuFranklin GarciaKevin A. RothJeffrey N. BrucePeter CanollMarkus D. SiegelinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Georg Karpel-Massler Chiaki Tsuge Ishida Elena Bianchetti Yiru Zhang Chang Shu Takashi Tsujiuchi Matei A. Banu Franklin Garcia Kevin A. Roth Jeffrey N. Bruce Peter Canoll Markus D. Siegelin Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
description	Glioblastoma (GBM) cells are often characterized by the presence of the IDH1 R132H mutation and high expression of anti-apoptotic proteins. Here, the authors show that the inhibition of Bcl-xL is synthetically lethal in IDH1-mutated GBM models and that this effect is mediated by the oncometabolite, 2-HG, which reduces Mcl-1 protein levels.
format	article
author	Georg Karpel-Massler Chiaki Tsuge Ishida Elena Bianchetti Yiru Zhang Chang Shu Takashi Tsujiuchi Matei A. Banu Franklin Garcia Kevin A. Roth Jeffrey N. Bruce Peter Canoll Markus D. Siegelin
author_facet	Georg Karpel-Massler Chiaki Tsuge Ishida Elena Bianchetti Yiru Zhang Chang Shu Takashi Tsujiuchi Matei A. Banu Franklin Garcia Kevin A. Roth Jeffrey N. Bruce Peter Canoll Markus D. Siegelin
author_sort	Georg Karpel-Massler
title	Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
title_short	Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
title_full	Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
title_fullStr	Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
title_full_unstemmed	Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL
title_sort	induction of synthetic lethality in idh1-mutated gliomas through inhibition of bcl-xl
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0f3f4c1834e24518860d56a1a35c45d4
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Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL

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