Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

In mature neurons the centrosome no longer functions as the main microtubule organizer and it is unclear how ordered microtubule arrays are assembled. Here, the authors show that in post-mitotic neurons this process depends on non-centrosomal nucleation mediated by the protein complex augmin and the...

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Autores principales:	Carlos Sánchez-Huertas, Francisco Freixo, Ricardo Viais, Cristina Lacasa, Eduardo Soriano, Jens Lüders
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f411a4f04684af1bd2378a4147d5c2c
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spelling	oai:doaj.org-article:0f411a4f04684af1bd2378a4147d5c2c2021-12-02T14:39:54ZNon-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity10.1038/ncomms121872041-1723https://doaj.org/article/0f411a4f04684af1bd2378a4147d5c2c2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12187https://doaj.org/toc/2041-1723In mature neurons the centrosome no longer functions as the main microtubule organizer and it is unclear how ordered microtubule arrays are assembled. Here, the authors show that in post-mitotic neurons this process depends on non-centrosomal nucleation mediated by the protein complex augmin and the nucleator gamma-TuRC.Carlos Sánchez-HuertasFrancisco FreixoRicardo ViaisCristina LacasaEduardo SorianoJens LüdersNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carlos Sánchez-Huertas Francisco Freixo Ricardo Viais Cristina Lacasa Eduardo Soriano Jens Lüders Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
description	In mature neurons the centrosome no longer functions as the main microtubule organizer and it is unclear how ordered microtubule arrays are assembled. Here, the authors show that in post-mitotic neurons this process depends on non-centrosomal nucleation mediated by the protein complex augmin and the nucleator gamma-TuRC.
format	article
author	Carlos Sánchez-Huertas Francisco Freixo Ricardo Viais Cristina Lacasa Eduardo Soriano Jens Lüders
author_facet	Carlos Sánchez-Huertas Francisco Freixo Ricardo Viais Cristina Lacasa Eduardo Soriano Jens Lüders
author_sort	Carlos Sánchez-Huertas
title	Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
title_short	Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
title_full	Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
title_fullStr	Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
title_full_unstemmed	Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
title_sort	non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0f411a4f04684af1bd2378a4147d5c2c
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Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity

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