Microglia innately develop within cerebral organoids

Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment.

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Autores principales:	Paul R. Ormel, Renata Vieira de Sá, Emma J. van Bodegraven, Henk Karst, Oliver Harschnitz, Marjolein A. M. Sneeboer, Lill Eva Johansen, Roland E. van Dijk, Nicky Scheefhals, Amber Berdenis van Berlekom, Eduardo Ribes Martínez, Sandra Kling, Harold D. MacGillavry, Leonard H. van den Berg, René S. Kahn, Elly M. Hol, Lot D. de Witte, R. Jeroen Pasterkamp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f43c1e80fff44ada197169a4b75a7dc
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spelling	oai:doaj.org-article:0f43c1e80fff44ada197169a4b75a7dc2021-12-02T14:40:04ZMicroglia innately develop within cerebral organoids10.1038/s41467-018-06684-22041-1723https://doaj.org/article/0f43c1e80fff44ada197169a4b75a7dc2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06684-2https://doaj.org/toc/2041-1723Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment.Paul R. OrmelRenata Vieira de SáEmma J. van BodegravenHenk KarstOliver HarschnitzMarjolein A. M. SneeboerLill Eva JohansenRoland E. van DijkNicky ScheefhalsAmber Berdenis van BerlekomEduardo Ribes MartínezSandra KlingHarold D. MacGillavryLeonard H. van den BergRené S. KahnElly M. HolLot D. de WitteR. Jeroen PasterkampNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul R. Ormel Renata Vieira de Sá Emma J. van Bodegraven Henk Karst Oliver Harschnitz Marjolein A. M. Sneeboer Lill Eva Johansen Roland E. van Dijk Nicky Scheefhals Amber Berdenis van Berlekom Eduardo Ribes Martínez Sandra Kling Harold D. MacGillavry Leonard H. van den Berg René S. Kahn Elly M. Hol Lot D. de Witte R. Jeroen Pasterkamp Microglia innately develop within cerebral organoids
description	Brain organoid models reported to date lack cells of mesodermal origin, such as microglia. Here, the authors demonstrate that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human microglia in a three-dimensional brain environment.
format	article
author	Paul R. Ormel Renata Vieira de Sá Emma J. van Bodegraven Henk Karst Oliver Harschnitz Marjolein A. M. Sneeboer Lill Eva Johansen Roland E. van Dijk Nicky Scheefhals Amber Berdenis van Berlekom Eduardo Ribes Martínez Sandra Kling Harold D. MacGillavry Leonard H. van den Berg René S. Kahn Elly M. Hol Lot D. de Witte R. Jeroen Pasterkamp
author_facet	Paul R. Ormel Renata Vieira de Sá Emma J. van Bodegraven Henk Karst Oliver Harschnitz Marjolein A. M. Sneeboer Lill Eva Johansen Roland E. van Dijk Nicky Scheefhals Amber Berdenis van Berlekom Eduardo Ribes Martínez Sandra Kling Harold D. MacGillavry Leonard H. van den Berg René S. Kahn Elly M. Hol Lot D. de Witte R. Jeroen Pasterkamp
author_sort	Paul R. Ormel
title	Microglia innately develop within cerebral organoids
title_short	Microglia innately develop within cerebral organoids
title_full	Microglia innately develop within cerebral organoids
title_fullStr	Microglia innately develop within cerebral organoids
title_full_unstemmed	Microglia innately develop within cerebral organoids
title_sort	microglia innately develop within cerebral organoids
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0f43c1e80fff44ada197169a4b75a7dc
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Microglia innately develop within cerebral organoids

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