Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population

Abstract The purpose was to explore the effects of resting heart rate (RHR) and pulse pressure (PP) independently as well as their cumulative effects on the risk of type 2 diabetes mellitus (T2DM) through cross-sectional study plus meta-analysis. A total of 8276 subjects aged 35–74 years from the Ru...

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Autores principales:	Panpan Wang, Yuqian Li, Xiaotian Liu, Quanxin Wang, Ying Guo, Yang Zhao, Linlin Li, Jingjing Fan, Hao Zhou, Zhenxing Mao, Gongyuan Zhang, Chongjian Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f4465ad1f3544a39c63e6c531b74478
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spelling	oai:doaj.org-article:0f4465ad1f3544a39c63e6c531b744782021-12-02T11:52:32ZIndependent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population10.1038/s41598-017-02758-12045-2322https://doaj.org/article/0f4465ad1f3544a39c63e6c531b744782017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02758-1https://doaj.org/toc/2045-2322Abstract The purpose was to explore the effects of resting heart rate (RHR) and pulse pressure (PP) independently as well as their cumulative effects on the risk of type 2 diabetes mellitus (T2DM) through cross-sectional study plus meta-analysis. A total of 8276 subjects aged 35–74 years from the Rural Diabetes, Obesity and Lifestyle (RuralDiab) study were included in the study. Meanwhile, two meta-analyses were conducted to validate the results of the epidemiological research. The results showed that RHR and PP were associated with higher risk of T2DM, and the corresponding adjusted OR(95%CI) for each quartiles were 1.00, 0.99(0.68–1.42), 1.58(1.13–2.20), 2.93(2.15–3.98) and 1.00, 1.06(0.75–1.48), 1.11(0.79–1.56), 1.45(1.03–2.03), respectively. The cumulative effect analysis indicated that the adjusted OR(95%CI) in the fast RHR-high PP were 3.36(2.26–4.99), 2.60(1.47–4.59), and 3.60(2.09–6.20) compared with the slow RHR-low PP for total population, male and female, respectively. Meta-analysis showed that the pooled effect values for RHR and PP were 1.94(1.64–2.31) and 1.25(1.04–1.51), respectively. This study demonstrated that elevated RHR and PP are independently associated with the risk of T2DM as well as the influences of conventional confounders, and fast RHR with high PP might cumulatively increase the risk of T2DM. However, the potential clinical application remains to be determined.Panpan WangYuqian LiXiaotian LiuQuanxin WangYing GuoYang ZhaoLinlin LiJingjing FanHao ZhouZhenxing MaoGongyuan ZhangChongjian WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Panpan Wang Yuqian Li Xiaotian Liu Quanxin Wang Ying Guo Yang Zhao Linlin Li Jingjing Fan Hao Zhou Zhenxing Mao Gongyuan Zhang Chongjian Wang Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population
description	Abstract The purpose was to explore the effects of resting heart rate (RHR) and pulse pressure (PP) independently as well as their cumulative effects on the risk of type 2 diabetes mellitus (T2DM) through cross-sectional study plus meta-analysis. A total of 8276 subjects aged 35–74 years from the Rural Diabetes, Obesity and Lifestyle (RuralDiab) study were included in the study. Meanwhile, two meta-analyses were conducted to validate the results of the epidemiological research. The results showed that RHR and PP were associated with higher risk of T2DM, and the corresponding adjusted OR(95%CI) for each quartiles were 1.00, 0.99(0.68–1.42), 1.58(1.13–2.20), 2.93(2.15–3.98) and 1.00, 1.06(0.75–1.48), 1.11(0.79–1.56), 1.45(1.03–2.03), respectively. The cumulative effect analysis indicated that the adjusted OR(95%CI) in the fast RHR-high PP were 3.36(2.26–4.99), 2.60(1.47–4.59), and 3.60(2.09–6.20) compared with the slow RHR-low PP for total population, male and female, respectively. Meta-analysis showed that the pooled effect values for RHR and PP were 1.94(1.64–2.31) and 1.25(1.04–1.51), respectively. This study demonstrated that elevated RHR and PP are independently associated with the risk of T2DM as well as the influences of conventional confounders, and fast RHR with high PP might cumulatively increase the risk of T2DM. However, the potential clinical application remains to be determined.
format	article
author	Panpan Wang Yuqian Li Xiaotian Liu Quanxin Wang Ying Guo Yang Zhao Linlin Li Jingjing Fan Hao Zhou Zhenxing Mao Gongyuan Zhang Chongjian Wang
author_facet	Panpan Wang Yuqian Li Xiaotian Liu Quanxin Wang Ying Guo Yang Zhao Linlin Li Jingjing Fan Hao Zhou Zhenxing Mao Gongyuan Zhang Chongjian Wang
author_sort	Panpan Wang
title	Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population
title_short	Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population
title_full	Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population
title_fullStr	Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population
title_full_unstemmed	Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population
title_sort	independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in chinese rural population
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0f4465ad1f3544a39c63e6c531b74478
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Independent and cumulative effects of resting heart rate and pulse pressure with type 2 diabetes mellitus in Chinese rural population

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