Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.

<h4>Objectives</h4>To estimate the seroprevalence of Chlamydia trachomatis (CT), herpes simplex type-2 (HSV2), hepatitis C (HCV), Epstein-Barr virus (EBV) and nine human papilloma virus (HPV) types, and investigated factors associated with the seropositivity among men from three countrie...

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Autores principales:	Shams Rahman, Deanna Wathington, Tim Waterboer, Michael Pawlita, Luisa L Villa, Eduardo Lazcano-Ponce, Martina Willhauck-Fleckenstein, Nicole Brenner, Anna R Giuliano
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f461a18cfa74712b201436cd940e61c
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spelling	oai:doaj.org-article:0f461a18cfa74712b201436cd940e61c2021-12-02T20:15:47ZSeroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.1932-620310.1371/journal.pone.0253005https://doaj.org/article/0f461a18cfa74712b201436cd940e61c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253005https://doaj.org/toc/1932-6203<h4>Objectives</h4>To estimate the seroprevalence of Chlamydia trachomatis (CT), herpes simplex type-2 (HSV2), hepatitis C (HCV), Epstein-Barr virus (EBV) and nine human papilloma virus (HPV) types, and investigated factors associated with the seropositivity among men from three countries (Brazil, Mexico and U.S).<h4>Methods</h4>Archived serum specimens collected at enrollment for n = 600 men were tested for antibodies against CT, HSV2, HCV, EBV, and 9-valent HPV vaccine types (6/11/16/18/31/33/45/52/58) using multiplex serologic assays. Socio-demographic, lifestyle and sexual behavior data at enrollment were collected through a questionnaire.<h4>Results</h4>Overall, 39.3% of the men were seropositive for CT, 25.4% for HSV2, 1.3% for HCV, 97.3% for EBV, 14.0% for at least one of the seven oncogenic HPV (types: 16/18/31/33/45/52/58), and 17.4% for HPV 6/11. In the unadjusted models, age, race, smoking, sexual behavior variables, and seropositivity for high-risk HPV were significantly associated with the seropositivity for CT. In multivariable analyses, self-reported black race, higher numbers of lifetime female/male sexual partners, current smoking, and seropositivity to high-risk HPV were significantly associated with increased odds of CT seropositivity. Odds of HSV2 seroprevalence were elevated among older men and those seropositive for high risk HPV.<h4>Conclusion</h4>Exposure to STIs is common among men. Prevention and screening programs should target high-risk groups to reduce the disease burden among men, and to interrupt the disease transmission to sexual partners.Shams RahmanDeanna WathingtonTim WaterboerMichael PawlitaLuisa L VillaEduardo Lazcano-PonceMartina Willhauck-FleckensteinNicole BrennerAnna R GiulianoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253005 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shams Rahman Deanna Wathington Tim Waterboer Michael Pawlita Luisa L Villa Eduardo Lazcano-Ponce Martina Willhauck-Fleckenstein Nicole Brenner Anna R Giuliano Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.
description	<h4>Objectives</h4>To estimate the seroprevalence of Chlamydia trachomatis (CT), herpes simplex type-2 (HSV2), hepatitis C (HCV), Epstein-Barr virus (EBV) and nine human papilloma virus (HPV) types, and investigated factors associated with the seropositivity among men from three countries (Brazil, Mexico and U.S).<h4>Methods</h4>Archived serum specimens collected at enrollment for n = 600 men were tested for antibodies against CT, HSV2, HCV, EBV, and 9-valent HPV vaccine types (6/11/16/18/31/33/45/52/58) using multiplex serologic assays. Socio-demographic, lifestyle and sexual behavior data at enrollment were collected through a questionnaire.<h4>Results</h4>Overall, 39.3% of the men were seropositive for CT, 25.4% for HSV2, 1.3% for HCV, 97.3% for EBV, 14.0% for at least one of the seven oncogenic HPV (types: 16/18/31/33/45/52/58), and 17.4% for HPV 6/11. In the unadjusted models, age, race, smoking, sexual behavior variables, and seropositivity for high-risk HPV were significantly associated with the seropositivity for CT. In multivariable analyses, self-reported black race, higher numbers of lifetime female/male sexual partners, current smoking, and seropositivity to high-risk HPV were significantly associated with increased odds of CT seropositivity. Odds of HSV2 seroprevalence were elevated among older men and those seropositive for high risk HPV.<h4>Conclusion</h4>Exposure to STIs is common among men. Prevention and screening programs should target high-risk groups to reduce the disease burden among men, and to interrupt the disease transmission to sexual partners.
format	article
author	Shams Rahman Deanna Wathington Tim Waterboer Michael Pawlita Luisa L Villa Eduardo Lazcano-Ponce Martina Willhauck-Fleckenstein Nicole Brenner Anna R Giuliano
author_facet	Shams Rahman Deanna Wathington Tim Waterboer Michael Pawlita Luisa L Villa Eduardo Lazcano-Ponce Martina Willhauck-Fleckenstein Nicole Brenner Anna R Giuliano
author_sort	Shams Rahman
title	Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.
title_short	Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.
title_full	Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.
title_fullStr	Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.
title_full_unstemmed	Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.
title_sort	seroprevalence of chlamydia trachomatis, herpes simplex 2, epstein-barr virus, hepatitis c and associated factors among a cohort of men ages 18-70 years from three countries.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/0f461a18cfa74712b201436cd940e61c
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Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.

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