Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers

While resistance to antiviral drugs can hinder their clinical use, understanding resistance mechanisms can illuminate how these drugs and their targets act. We studied a substitution in the human cytomegalovirus (HCMV) DNA polymerase that confers resistance to a leading anti-HCMV drug, ganciclovir.

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Autores principales:	Han Chen, Jessica L. Lawler, David J. Filman, James M. Hogle, Donald M. Coen
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0f46903a19ac46bc9b2f75df1b75364b
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spelling	oai:doaj.org-article:0f46903a19ac46bc9b2f75df1b75364b2021-11-03T18:15:38ZResistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers2161-21292150-751110.1128/mBio.03492-20https://doaj.org/article/0f46903a19ac46bc9b2f75df1b75364b2021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03492-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 While resistance to antiviral drugs can hinder their clinical use, understanding resistance mechanisms can illuminate how these drugs and their targets act. We studied a substitution in the human cytomegalovirus (HCMV) DNA polymerase that confers resistance to a leading anti-HCMV drug, ganciclovir.Han ChenJessica L. LawlerDavid J. FilmanJames M. HogleDonald M. CoenAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Han Chen Jessica L. Lawler David J. Filman James M. Hogle Donald M. Coen Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers
description	While resistance to antiviral drugs can hinder their clinical use, understanding resistance mechanisms can illuminate how these drugs and their targets act. We studied a substitution in the human cytomegalovirus (HCMV) DNA polymerase that confers resistance to a leading anti-HCMV drug, ganciclovir.
format	article
author	Han Chen Jessica L. Lawler David J. Filman James M. Hogle Donald M. Coen
author_facet	Han Chen Jessica L. Lawler David J. Filman James M. Hogle Donald M. Coen
author_sort	Han Chen
title	Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers
title_short	Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers
title_full	Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers
title_fullStr	Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers
title_full_unstemmed	Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers
title_sort	resistance to a nucleoside analog antiviral drug from more rapid extension of drug-containing primers
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/0f46903a19ac46bc9b2f75df1b75364b
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Resistance to a Nucleoside Analog Antiviral Drug from More Rapid Extension of Drug-Containing Primers

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