Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities

Objective: This study aimed to determine the association between hyperuricemia, comorbid diseases and risk of developing gout disease in a Turkish population in a long follow-up period. Methods: A total of 2000 Turkish adults were cross-sectionally analysed for serum urate levels in 2009 at the Pamu...

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Autores principales:	Firdevs Ulutaş, Aslı Bozdemir, Nevzat Atalay Çelikyürek, Canan Albayrak Yaşar, Veli Çobankara
Formato:	article
Lenguaje:	EN
Publicado:	PCO Convin S.A. 2021
Materias:	hyperuricemia gout co-morbid disease cut-off Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/0f529d927b3e42e8ac44f9d3a60251e0
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spelling	oai:doaj.org-article:0f529d927b3e42e8ac44f9d3a60251e02021-11-08T08:28:47ZCut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities2529-198X10.31138/mjr.32.3.243https://doaj.org/article/0f529d927b3e42e8ac44f9d3a60251e02021-01-01T00:00:00Zhttp://www.mjrheum.org/assets/files/792/file332_1358.pdfhttps://doaj.org/toc/2529-198XObjective: This study aimed to determine the association between hyperuricemia, comorbid diseases and risk of developing gout disease in a Turkish population in a long follow-up period. Methods: A total of 2000 Turkish adults were cross-sectionally analysed for serum urate levels in 2009 at the Pamukkale University Faculty of Medicine. All patients on regular follow-up at our tertiary health center (n=1322) were included in this study. Demographic features (age and gender), comorbid clinical conditions, and medication use were noted. The risk of developing gout and the determinant factors were investigated. Multivariate logistic regression analysis was performed to analyse causative effects of factors while receiver operating characteristic (ROC) curve analysis was used to identify optimal cut-off values of uric acid level for predicting the development of gout. Results: Among 1322 patients, the mean age was 56.9 (SD:14.68) years. 57.3% (n=758) of the patients were female. The most common co-morbid disease was chronic kidney disease (581, 43%), followed by hypertension (522, 39.4%). Gout developed in 25 patients (1.8%). Gout development risk and presence of all the above comorbidities were significantly higher in patients with serum urate ≥7mg/dl compared with <7mg/dl. Male gender and not using urate lowering drugs were the main risk factors for developing gout disease. ROC analysis of serum uric acid levels identified a cut-off value of >7 (AUC: 0.776, sensitivity 86.96%, specificity 66.74%). Conclusion: There is still a dilemma concerning the culprit effects of both comorbidities and hyperuricemia on the risk of developing gout disease.Firdevs UlutaşAslı BozdemirNevzat Atalay ÇelikyürekCanan Albayrak YaşarVeli ÇobankaraPCO Convin S.A.articlehyperuricemiagoutco-morbid diseasecut-offDiseases of the musculoskeletal systemRC925-935ENMediterranean Journal of Rheumatology, Vol 32, Iss 3, Pp 243-248 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hyperuricemia gout co-morbid disease cut-off Diseases of the musculoskeletal system RC925-935
spellingShingle	hyperuricemia gout co-morbid disease cut-off Diseases of the musculoskeletal system RC925-935 Firdevs Ulutaş Aslı Bozdemir Nevzat Atalay Çelikyürek Canan Albayrak Yaşar Veli Çobankara Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities
description	Objective: This study aimed to determine the association between hyperuricemia, comorbid diseases and risk of developing gout disease in a Turkish population in a long follow-up period. Methods: A total of 2000 Turkish adults were cross-sectionally analysed for serum urate levels in 2009 at the Pamukkale University Faculty of Medicine. All patients on regular follow-up at our tertiary health center (n=1322) were included in this study. Demographic features (age and gender), comorbid clinical conditions, and medication use were noted. The risk of developing gout and the determinant factors were investigated. Multivariate logistic regression analysis was performed to analyse causative effects of factors while receiver operating characteristic (ROC) curve analysis was used to identify optimal cut-off values of uric acid level for predicting the development of gout. Results: Among 1322 patients, the mean age was 56.9 (SD:14.68) years. 57.3% (n=758) of the patients were female. The most common co-morbid disease was chronic kidney disease (581, 43%), followed by hypertension (522, 39.4%). Gout developed in 25 patients (1.8%). Gout development risk and presence of all the above comorbidities were significantly higher in patients with serum urate ≥7mg/dl compared with <7mg/dl. Male gender and not using urate lowering drugs were the main risk factors for developing gout disease. ROC analysis of serum uric acid levels identified a cut-off value of >7 (AUC: 0.776, sensitivity 86.96%, specificity 66.74%). Conclusion: There is still a dilemma concerning the culprit effects of both comorbidities and hyperuricemia on the risk of developing gout disease.
format	article
author	Firdevs Ulutaş Aslı Bozdemir Nevzat Atalay Çelikyürek Canan Albayrak Yaşar Veli Çobankara
author_facet	Firdevs Ulutaş Aslı Bozdemir Nevzat Atalay Çelikyürek Canan Albayrak Yaşar Veli Çobankara
author_sort	Firdevs Ulutaş
title	Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities
title_short	Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities
title_full	Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities
title_fullStr	Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities
title_full_unstemmed	Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities
title_sort	cut-off value of serum uric acid for development of gout disease in patients with multiple co-morbidities
publisher	PCO Convin S.A.
publishDate	2021
url	https://doaj.org/article/0f529d927b3e42e8ac44f9d3a60251e0
work_keys_str_mv	AT firdevsulutas cutoffvalueofserumuricacidfordevelopmentofgoutdiseaseinpatientswithmultiplecomorbidities AT aslıbozdemir cutoffvalueofserumuricacidfordevelopmentofgoutdiseaseinpatientswithmultiplecomorbidities AT nevzatatalaycelikyurek cutoffvalueofserumuricacidfordevelopmentofgoutdiseaseinpatientswithmultiplecomorbidities AT cananalbayrakyasar cutoffvalueofserumuricacidfordevelopmentofgoutdiseaseinpatientswithmultiplecomorbidities AT velicobankara cutoffvalueofserumuricacidfordevelopmentofgoutdiseaseinpatientswithmultiplecomorbidities
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Cut-Off Value of Serum Uric Acid for Development of Gout Disease in Patients with Multiple Co-Morbidities

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