Decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer

The aim of this study was to evaluate the association of the chromobox homologue 7 (CBX7) expression with the epithelial–mesenchymal transition in cervical cancer (CC), as well as with the disease prognosis. CBX7, E-cadherin (E-cad), and vimentin (VIM) expression levels were detected with immunohist...

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Autores principales:	Tian Ping, Zhang Chen, Ma Cailing, Ding Lu, Tao Ning, Ning Li, Wang Yan, Yong Xianting, Yan Qi, Lin Xin, Wang Jing, Li Rong
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	cervical cancer chromobox homologue 7 epithelia–mesenchymal transition e-cadherin prognosis Medicine R
Acceso en línea:	https://doaj.org/article/0f54aad381364d3cbd5cead3bc5ba813
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spelling	oai:doaj.org-article:0f54aad381364d3cbd5cead3bc5ba8132021-12-05T14:10:53ZDecreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer2391-546310.1515/med-2021-0015https://doaj.org/article/0f54aad381364d3cbd5cead3bc5ba8132021-03-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0015https://doaj.org/toc/2391-5463The aim of this study was to evaluate the association of the chromobox homologue 7 (CBX7) expression with the epithelial–mesenchymal transition in cervical cancer (CC), as well as with the disease prognosis. CBX7, E-cadherin (E-cad), and vimentin (VIM) expression levels were detected with immunohistochemistry. The relationship between the expression of CBX7, E-cad, and VIM expression and conventional clinicopathological characteristics of CC were evaluated. The positive expression rates of CBX7 and E-cad in the CC tissues were lower than the adjacent non-tumorous cervical tissues. Moreover, the VIM expression level was higher. The CBX7 expression was positively correlated with the E-cad expression, whereas was negatively correlated with the VIM expression. Furthermore, CBX7 was associated with the disease clinical staging, histological differentiation, lymph node metastasis, and vascular invasion. Patients with negative CBX7 expression showed decreased overall survival rates compared with those with low or high CBX7 expression. Multivariate Cox regression analysis indicated that the decreased CBX7 expression was an independent predictor for the poor prognosis of CC. In conclusion, the absence of CBX7 is associated with the histologic differentiation, lymphatic metastasis, vascular invasion, and poor prognosis of CC. CBX7 may be an independent prognostic factor for the prognosis of CC patients.Tian PingZhang ChenMa CailingDing LuTao NingNing LiWang YanYong XiantingYan QiLin XinWang JingLi RongDe Gruyterarticlecervical cancerchromobox homologue 7epithelia–mesenchymal transitione-cadherinprognosisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 410-418 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cervical cancer chromobox homologue 7 epithelia–mesenchymal transition e-cadherin prognosis Medicine R
spellingShingle	cervical cancer chromobox homologue 7 epithelia–mesenchymal transition e-cadherin prognosis Medicine R Tian Ping Zhang Chen Ma Cailing Ding Lu Tao Ning Ning Li Wang Yan Yong Xianting Yan Qi Lin Xin Wang Jing Li Rong Decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer
description	The aim of this study was to evaluate the association of the chromobox homologue 7 (CBX7) expression with the epithelial–mesenchymal transition in cervical cancer (CC), as well as with the disease prognosis. CBX7, E-cadherin (E-cad), and vimentin (VIM) expression levels were detected with immunohistochemistry. The relationship between the expression of CBX7, E-cad, and VIM expression and conventional clinicopathological characteristics of CC were evaluated. The positive expression rates of CBX7 and E-cad in the CC tissues were lower than the adjacent non-tumorous cervical tissues. Moreover, the VIM expression level was higher. The CBX7 expression was positively correlated with the E-cad expression, whereas was negatively correlated with the VIM expression. Furthermore, CBX7 was associated with the disease clinical staging, histological differentiation, lymph node metastasis, and vascular invasion. Patients with negative CBX7 expression showed decreased overall survival rates compared with those with low or high CBX7 expression. Multivariate Cox regression analysis indicated that the decreased CBX7 expression was an independent predictor for the poor prognosis of CC. In conclusion, the absence of CBX7 is associated with the histologic differentiation, lymphatic metastasis, vascular invasion, and poor prognosis of CC. CBX7 may be an independent prognostic factor for the prognosis of CC patients.
format	article
author	Tian Ping Zhang Chen Ma Cailing Ding Lu Tao Ning Ning Li Wang Yan Yong Xianting Yan Qi Lin Xin Wang Jing Li Rong
author_facet	Tian Ping Zhang Chen Ma Cailing Ding Lu Tao Ning Ning Li Wang Yan Yong Xianting Yan Qi Lin Xin Wang Jing Li Rong
author_sort	Tian Ping
title	Decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer
title_short	Decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer
title_full	Decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer
title_fullStr	Decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer
title_full_unstemmed	Decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer
title_sort	decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/0f54aad381364d3cbd5cead3bc5ba813
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Decreased chromobox homologue 7 expression is associated with epithelial–mesenchymal transition and poor prognosis in cervical cancer

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