BLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS

Laboratory parameters of IgE-mediated immunological reaction (total IgE) were studied. Subjects with impaired carbohydrate metabolism and persons with diabetes mellitus were classified for blood groups 0(I), A(II), B(III) (n = 93). We determined total IgE, glucose levels and percentage of glycosylat...

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Autores principales:	N. R. Telesmanich, M. A. Konovalchik, Z. I. Mikashinovich, E. G. Krivolapova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	blood group (ab0) diabetes disorders of carbohydrate metabolism immunologic markers antibodies Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0f5505d78bbb49cca47e0f62eca25096
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spelling	oai:doaj.org-article:0f5505d78bbb49cca47e0f62eca250962021-11-18T08:03:46ZBLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS1563-06252313-741X10.15789/1563-0625-2017-6-789-796https://doaj.org/article/0f5505d78bbb49cca47e0f62eca250962017-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1403https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XLaboratory parameters of IgE-mediated immunological reaction (total IgE) were studied. Subjects with impaired carbohydrate metabolism and persons with diabetes mellitus were classified for blood groups 0(I), A(II), B(III) (n = 93). We determined total IgE, glucose levels and percentage of glycosylated hemoglobin (HbA1c) in blood serum; as well ABO blood groups. Comparison of these parameters in patient cohorts with 0(I) and A(II), B(III) blood groups showed different reactogenicity, depending on the degree of carbohydrate metabolism disturbance and ABO group specificity of antigenic determinants of blood glycoproteins. There was a strong direct correlation (r = 0.8) between blood group 0(I) antigens, and incidence of type 2 diabetes mellitus (DM). The highest correlation degree was observed between the blood group A(II) and type 1 diabetes onset of (r = 1.0). The smallest percentage of DM and the smallest correlation (r = 0.67) were observed in patients, B(III) blood group is located. In cases of sufficiently altered carbohydrate metabolism, the blood group 0(I) and A(II) carriers had total IgE of 43.61±15.12 kIU/L, and 86.2±42.61 kIU/L, respectively, thus being, on average, 4-times lower than in B(III) blood group in whom total IgE in type 2 diabetes was 2-fold higher than normal values, being 209.65±52.5 kIU/L.N. R. TelesmanichM. A. KonovalchikZ. I. MikashinovichE. G. KrivolapovaSPb RAACIarticleblood group (ab0)diabetesdisorders of carbohydrate metabolismimmunologic markersantibodiesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 6, Pp 789-796 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	blood group (ab0) diabetes disorders of carbohydrate metabolism immunologic markers antibodies Immunologic diseases. Allergy RC581-607
spellingShingle	blood group (ab0) diabetes disorders of carbohydrate metabolism immunologic markers antibodies Immunologic diseases. Allergy RC581-607 N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova BLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS
description	Laboratory parameters of IgE-mediated immunological reaction (total IgE) were studied. Subjects with impaired carbohydrate metabolism and persons with diabetes mellitus were classified for blood groups 0(I), A(II), B(III) (n = 93). We determined total IgE, glucose levels and percentage of glycosylated hemoglobin (HbA1c) in blood serum; as well ABO blood groups. Comparison of these parameters in patient cohorts with 0(I) and A(II), B(III) blood groups showed different reactogenicity, depending on the degree of carbohydrate metabolism disturbance and ABO group specificity of antigenic determinants of blood glycoproteins. There was a strong direct correlation (r = 0.8) between blood group 0(I) antigens, and incidence of type 2 diabetes mellitus (DM). The highest correlation degree was observed between the blood group A(II) and type 1 diabetes onset of (r = 1.0). The smallest percentage of DM and the smallest correlation (r = 0.67) were observed in patients, B(III) blood group is located. In cases of sufficiently altered carbohydrate metabolism, the blood group 0(I) and A(II) carriers had total IgE of 43.61±15.12 kIU/L, and 86.2±42.61 kIU/L, respectively, thus being, on average, 4-times lower than in B(III) blood group in whom total IgE in type 2 diabetes was 2-fold higher than normal values, being 209.65±52.5 kIU/L.
format	article
author	N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova
author_facet	N. R. Telesmanich M. A. Konovalchik Z. I. Mikashinovich E. G. Krivolapova
author_sort	N. R. Telesmanich
title	BLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS
title_short	BLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS
title_full	BLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS
title_fullStr	BLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS
title_full_unstemmed	BLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS
title_sort	blood group antigen-dependent features of polyclonal ige-response in carbohydrate metabolic disorders
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/0f5505d78bbb49cca47e0f62eca25096
work_keys_str_mv	AT nrtelesmanich bloodgroupantigendependentfeaturesofpolyclonaligeresponseincarbohydratemetabolicdisorders AT makonovalchik bloodgroupantigendependentfeaturesofpolyclonaligeresponseincarbohydratemetabolicdisorders AT zimikashinovich bloodgroupantigendependentfeaturesofpolyclonaligeresponseincarbohydratemetabolicdisorders AT egkrivolapova bloodgroupantigendependentfeaturesofpolyclonaligeresponseincarbohydratemetabolicdisorders
_version_	1718422396184035328

BLOOD GROUP ANTIGEN-DEPENDENT FEATURES OF POLYCLONAL IgE-RESPONSE IN CARBOHYDRATE METABOLIC DISORDERS

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