Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.

Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.

IRGM and its mouse orthologue Irgm1 are dynamin-like proteins that regulate vesicular remodeling, intracellular microbial killing, and pathogen immunity. IRGM dysfunction is linked to inflammatory bowel disease (IBD), and while it is thought that defective intracellular killing of microbes underscor...

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Autores principales: Gregory A Taylor, Hsin-I Huang, Brian E Fee, Nourhan Youssef, Mark L Jewell, Viviana Cantillana, Alexi A Schoenborn, Allison R Rogala, Anne F Buckley, Carl G Feng, Bruce A Vallance, Ajay S Gulati, Gianna E Hammer
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2020
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/0f551c4084a24ce09013efa7ff036e98
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