Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

Abstract Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in h...

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Autores principales:	Stephanie Kullmann, Martin Heni, Ralf Veit, Klaus Scheffler, Jürgen Machann, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f57647e169345e7997bf87ecc6a7a45
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spelling	oai:doaj.org-article:0f57647e169345e7997bf87ecc6a7a452021-12-02T15:06:21ZIntranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger10.1038/s41598-017-01907-w2045-2322https://doaj.org/article/0f57647e169345e7997bf87ecc6a7a452017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01907-whttps://doaj.org/toc/2045-2322Abstract Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-five lean and twenty-two overweight and obese participants underwent functional magnetic resonance imaging, on two separate days, before and after intranasal insulin or placebo application. Insulin compared to placebo administration resulted in increased functional connectivity between the prefrontal regions of the default-mode network and the hippocampus as well as the hypothalamus. The change in hippocampal functional connectivity significantly correlated with visceral adipose tissue and the change in subjective feeling of hunger after intranasal insulin. Mediation analysis revealed that the intranasal insulin induced hippocampal functional connectivity increase served as a mediator, suppressing the relationship between visceral adipose tissue and hunger. The insulin-induced hypothalamic functional connectivity change showed a significant interaction with peripheral insulin sensitivity. Only participants with high peripheral insulin sensitivity showed a boost in hypothalamic functional connectivity. Hence, brain insulin action may regulate eating behavior and facilitate weight loss by modifying brain functional connectivity within and between cognitive and homeostatic brain regions.Stephanie KullmannMartin HeniRalf VeitKlaus SchefflerJürgen MachannHans-Ulrich HäringAndreas FritscheHubert PreisslNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stephanie Kullmann Martin Heni Ralf Veit Klaus Scheffler Jürgen Machann Hans-Ulrich Häring Andreas Fritsche Hubert Preissl Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
description	Abstract Brain insulin sensitivity is an important link between metabolism and cognitive dysfunction. Intranasal insulin is a promising tool to investigate central insulin action in humans. We evaluated the acute effects of 160 U intranasal insulin on resting-state brain functional connectivity in healthy young adults. Twenty-five lean and twenty-two overweight and obese participants underwent functional magnetic resonance imaging, on two separate days, before and after intranasal insulin or placebo application. Insulin compared to placebo administration resulted in increased functional connectivity between the prefrontal regions of the default-mode network and the hippocampus as well as the hypothalamus. The change in hippocampal functional connectivity significantly correlated with visceral adipose tissue and the change in subjective feeling of hunger after intranasal insulin. Mediation analysis revealed that the intranasal insulin induced hippocampal functional connectivity increase served as a mediator, suppressing the relationship between visceral adipose tissue and hunger. The insulin-induced hypothalamic functional connectivity change showed a significant interaction with peripheral insulin sensitivity. Only participants with high peripheral insulin sensitivity showed a boost in hypothalamic functional connectivity. Hence, brain insulin action may regulate eating behavior and facilitate weight loss by modifying brain functional connectivity within and between cognitive and homeostatic brain regions.
format	article
author	Stephanie Kullmann Martin Heni Ralf Veit Klaus Scheffler Jürgen Machann Hans-Ulrich Häring Andreas Fritsche Hubert Preissl
author_facet	Stephanie Kullmann Martin Heni Ralf Veit Klaus Scheffler Jürgen Machann Hans-Ulrich Häring Andreas Fritsche Hubert Preissl
author_sort	Stephanie Kullmann
title	Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
title_short	Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
title_full	Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
title_fullStr	Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
title_full_unstemmed	Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
title_sort	intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0f57647e169345e7997bf87ecc6a7a45
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Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger

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