Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey
Abstract Although the incidence of hepatobiliary enzyme abnormality increased immediately after the Great East Japan Earthquake and subsequent Fukushima Daiichi Nuclear Power Plant accident, longer-term trends remain unclear. The aims of this study were to determine longer-term trends in hepatobilia...
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2017
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oai:doaj.org-article:0f580892b1ed468d80514034e53967c02021-12-02T15:05:53ZChanges in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey10.1038/s41598-017-00776-72045-2322https://doaj.org/article/0f580892b1ed468d80514034e53967c02017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00776-7https://doaj.org/toc/2045-2322Abstract Although the incidence of hepatobiliary enzyme abnormality increased immediately after the Great East Japan Earthquake and subsequent Fukushima Daiichi Nuclear Power Plant accident, longer-term trends remain unclear. The aims of this study were to determine longer-term trends in hepatobiliary enzyme abnormality and to elucidate lifestyle factors associated with such changes among residents of a nuclear-disaster-affected area. This longitudinal survey enrolled 20,395 adults living in the vicinity of Fukushima Daiichi Nuclear Power Plant. Data were obtained from the records of annual health checkups of adults aged ≥40 years between 2011 and 2012. Follow-up examinations were conducted from June 2013 to March 2014. Associations were assessed between changes in hepatobiliary enzyme abnormality immediately and 3–4 years after the disaster and lifestyle factors. The overall prevalence of hepatobiliary enzyme abnormality significantly decreased over the study period, from 29.9% to 27.1%. Multivariate logistic regression analysis revealed significant associations between improved hepatobiliary enzyme abnormality and improvements in daily physical activity and frequency of breakfast consumption. The results suggest that improvements in daily physical activity and frequency of breakfast consumption significantly reduced the incidence of hepatobiliary enzyme abnormality 3–4 years after the Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant accident.Atsushi TakahashiTetsuya OhiraMayu UemuraMitsuaki HosoyaSeiji YasumuraShigeatsu HashimotoHiromasa OhiraAkira SakaiAkira OhtsuruHiroaki SatohYukihiko KawasakiHitoshi SuzukiYoshihiro SugiuraHiroaki ShishidoYoshimitsu HayashiHideto TakahashiHironori NakanoGen KobashiKotaro OzasaHitoshi OhtoMasafumi AbeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Atsushi Takahashi Tetsuya Ohira Mayu Uemura Mitsuaki Hosoya Seiji Yasumura Shigeatsu Hashimoto Hiromasa Ohira Akira Sakai Akira Ohtsuru Hiroaki Satoh Yukihiko Kawasaki Hitoshi Suzuki Yoshihiro Sugiura Hiroaki Shishido Yoshimitsu Hayashi Hideto Takahashi Hironori Nakano Gen Kobashi Kotaro Ozasa Hitoshi Ohto Masafumi Abe Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey |
| description |
Abstract Although the incidence of hepatobiliary enzyme abnormality increased immediately after the Great East Japan Earthquake and subsequent Fukushima Daiichi Nuclear Power Plant accident, longer-term trends remain unclear. The aims of this study were to determine longer-term trends in hepatobiliary enzyme abnormality and to elucidate lifestyle factors associated with such changes among residents of a nuclear-disaster-affected area. This longitudinal survey enrolled 20,395 adults living in the vicinity of Fukushima Daiichi Nuclear Power Plant. Data were obtained from the records of annual health checkups of adults aged ≥40 years between 2011 and 2012. Follow-up examinations were conducted from June 2013 to March 2014. Associations were assessed between changes in hepatobiliary enzyme abnormality immediately and 3–4 years after the disaster and lifestyle factors. The overall prevalence of hepatobiliary enzyme abnormality significantly decreased over the study period, from 29.9% to 27.1%. Multivariate logistic regression analysis revealed significant associations between improved hepatobiliary enzyme abnormality and improvements in daily physical activity and frequency of breakfast consumption. The results suggest that improvements in daily physical activity and frequency of breakfast consumption significantly reduced the incidence of hepatobiliary enzyme abnormality 3–4 years after the Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant accident. |
| format |
article |
| author |
Atsushi Takahashi Tetsuya Ohira Mayu Uemura Mitsuaki Hosoya Seiji Yasumura Shigeatsu Hashimoto Hiromasa Ohira Akira Sakai Akira Ohtsuru Hiroaki Satoh Yukihiko Kawasaki Hitoshi Suzuki Yoshihiro Sugiura Hiroaki Shishido Yoshimitsu Hayashi Hideto Takahashi Hironori Nakano Gen Kobashi Kotaro Ozasa Hitoshi Ohto Masafumi Abe |
| author_facet |
Atsushi Takahashi Tetsuya Ohira Mayu Uemura Mitsuaki Hosoya Seiji Yasumura Shigeatsu Hashimoto Hiromasa Ohira Akira Sakai Akira Ohtsuru Hiroaki Satoh Yukihiko Kawasaki Hitoshi Suzuki Yoshihiro Sugiura Hiroaki Shishido Yoshimitsu Hayashi Hideto Takahashi Hironori Nakano Gen Kobashi Kotaro Ozasa Hitoshi Ohto Masafumi Abe |
| author_sort |
Atsushi Takahashi |
| title |
Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey |
| title_short |
Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey |
| title_full |
Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey |
| title_fullStr |
Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey |
| title_full_unstemmed |
Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey |
| title_sort |
changes in hepatobiliary enzyme abnormality after the great east japan earthquake: the fukushima health management survey |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0f580892b1ed468d80514034e53967c0 |
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