Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia

Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia

The oncogenic fusion protein AML1-ETO has the ability of AML1 to interact with DNA but blocks AML1-dependent transcription. Here the authors report that histone lysine methyltransferase EZH1 interacts with AML1-ETO and methylates AML1-ETO at lysine 43, promoting AML1-ETO transcriptional repression i...

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Autores principales: Liping Dou, Fei Yan, Jiuxia Pang, Dehua Zheng, Dandan Li, Li Gao, Lijun Wang, Yihan Xu, Jinlong Shi, Qian Wang, Lei Zhou, Na Shen, Puja Singh, Lili Wang, Yonghui Li, Yvchi Gao, Tao Liu, Chongjian Chen, Aref Al-Kali, Mark R. Litzow, Young-In Chi, Ann M. Bode, Chunhui Liu, Haojie Huang, Daihong Liu, Guido Marcucci, Shujun Liu, Li Yu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0f5994628b9f4f649b55f74f17cfe002
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spelling oai:doaj.org-article:0f5994628b9f4f649b55f74f17cfe0022021-12-02T17:01:29ZProtein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia10.1038/s41467-019-12960-62041-1723https://doaj.org/article/0f5994628b9f4f649b55f74f17cfe0022019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12960-6https://doaj.org/toc/2041-1723The oncogenic fusion protein AML1-ETO has the ability of AML1 to interact with DNA but blocks AML1-dependent transcription. Here the authors report that histone lysine methyltransferase EZH1 interacts with AML1-ETO and methylates AML1-ETO at lysine 43, promoting AML1-ETO transcriptional repression in leukemia.Liping DouFei YanJiuxia PangDehua ZhengDandan LiLi GaoLijun WangYihan XuJinlong ShiQian WangLei ZhouNa ShenPuja SinghLili WangYonghui LiYvchi GaoTao LiuChongjian ChenAref Al-KaliMark R. LitzowYoung-In ChiAnn M. BodeChunhui LiuHaojie HuangDaihong LiuGuido MarcucciShujun LiuLi YuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Liping Dou
Fei Yan
Jiuxia Pang
Dehua Zheng
Dandan Li
Li Gao
Lijun Wang
Yihan Xu
Jinlong Shi
Qian Wang
Lei Zhou
Na Shen
Puja Singh
Lili Wang
Yonghui Li
Yvchi Gao
Tao Liu
Chongjian Chen
Aref Al-Kali
Mark R. Litzow
Young-In Chi
Ann M. Bode
Chunhui Liu
Haojie Huang
Daihong Liu
Guido Marcucci
Shujun Liu
Li Yu
Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
description The oncogenic fusion protein AML1-ETO has the ability of AML1 to interact with DNA but blocks AML1-dependent transcription. Here the authors report that histone lysine methyltransferase EZH1 interacts with AML1-ETO and methylates AML1-ETO at lysine 43, promoting AML1-ETO transcriptional repression in leukemia.
format article
author Liping Dou
Fei Yan
Jiuxia Pang
Dehua Zheng
Dandan Li
Li Gao
Lijun Wang
Yihan Xu
Jinlong Shi
Qian Wang
Lei Zhou
Na Shen
Puja Singh
Lili Wang
Yonghui Li
Yvchi Gao
Tao Liu
Chongjian Chen
Aref Al-Kali
Mark R. Litzow
Young-In Chi
Ann M. Bode
Chunhui Liu
Haojie Huang
Daihong Liu
Guido Marcucci
Shujun Liu
Li Yu
author_facet Liping Dou
Fei Yan
Jiuxia Pang
Dehua Zheng
Dandan Li
Li Gao
Lijun Wang
Yihan Xu
Jinlong Shi
Qian Wang
Lei Zhou
Na Shen
Puja Singh
Lili Wang
Yonghui Li
Yvchi Gao
Tao Liu
Chongjian Chen
Aref Al-Kali
Mark R. Litzow
Young-In Chi
Ann M. Bode
Chunhui Liu
Haojie Huang
Daihong Liu
Guido Marcucci
Shujun Liu
Li Yu
author_sort Liping Dou
title Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
title_short Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
title_full Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
title_fullStr Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
title_full_unstemmed Protein lysine 43 methylation by EZH1 promotes AML1-ETO transcriptional repression in leukemia
title_sort protein lysine 43 methylation by ezh1 promotes aml1-eto transcriptional repression in leukemia
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/0f5994628b9f4f649b55f74f17cfe002
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