A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo

In vivo decorporation of U(VI) from bones is an unsolved challenge because of the formation of stable uranium phosphate complexes. Here, the authors develop a hydroxypyridonone-based ligand with strong uranium complexation and low cytotoxicity. They find this ligand effectively removes uranium from...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiaomei Wang, Xing Dai, Cen Shi, Jianmei Wan, Mark A. Silver, Linjuan Zhang, Lanhua Chen, Xuan Yi, Bizheng Chen, Duo Zhang, Kai Yang, Juan Diwu, Jianqiang Wang, Yujie Xu, Ruhong Zhou, Zhifang Chai, Shuao Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f5f19fdfda140a9b8a4128474a4e8c7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0f5f19fdfda140a9b8a4128474a4e8c7
record_format	dspace
spelling	oai:doaj.org-article:0f5f19fdfda140a9b8a4128474a4e8c72021-12-02T15:35:30ZA 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo10.1038/s41467-019-10276-z2041-1723https://doaj.org/article/0f5f19fdfda140a9b8a4128474a4e8c72019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10276-zhttps://doaj.org/toc/2041-1723In vivo decorporation of U(VI) from bones is an unsolved challenge because of the formation of stable uranium phosphate complexes. Here, the authors develop a hydroxypyridonone-based ligand with strong uranium complexation and low cytotoxicity. They find this ligand effectively removes uranium from kidney and bones in mice, and is suitable for oral administration.Xiaomei WangXing DaiCen ShiJianmei WanMark A. SilverLinjuan ZhangLanhua ChenXuan YiBizheng ChenDuo ZhangKai YangJuan DiwuJianqiang WangYujie XuRuhong ZhouZhifang ChaiShuao WangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaomei Wang Xing Dai Cen Shi Jianmei Wan Mark A. Silver Linjuan Zhang Lanhua Chen Xuan Yi Bizheng Chen Duo Zhang Kai Yang Juan Diwu Jianqiang Wang Yujie Xu Ruhong Zhou Zhifang Chai Shuao Wang A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
description	In vivo decorporation of U(VI) from bones is an unsolved challenge because of the formation of stable uranium phosphate complexes. Here, the authors develop a hydroxypyridonone-based ligand with strong uranium complexation and low cytotoxicity. They find this ligand effectively removes uranium from kidney and bones in mice, and is suitable for oral administration.
format	article
author	Xiaomei Wang Xing Dai Cen Shi Jianmei Wan Mark A. Silver Linjuan Zhang Lanhua Chen Xuan Yi Bizheng Chen Duo Zhang Kai Yang Juan Diwu Jianqiang Wang Yujie Xu Ruhong Zhou Zhifang Chai Shuao Wang
author_facet	Xiaomei Wang Xing Dai Cen Shi Jianmei Wan Mark A. Silver Linjuan Zhang Lanhua Chen Xuan Yi Bizheng Chen Duo Zhang Kai Yang Juan Diwu Jianqiang Wang Yujie Xu Ruhong Zhou Zhifang Chai Shuao Wang
author_sort	Xiaomei Wang
title	A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
title_short	A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
title_full	A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
title_fullStr	A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
title_full_unstemmed	A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
title_sort	3,2-hydroxypyridinone-based decorporation agent that removes uranium from bones in vivo
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0f5f19fdfda140a9b8a4128474a4e8c7
work_keys_str_mv	AT xiaomeiwang a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT xingdai a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT censhi a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT jianmeiwan a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT markasilver a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT linjuanzhang a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT lanhuachen a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT xuanyi a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT bizhengchen a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT duozhang a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT kaiyang a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT juandiwu a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT jianqiangwang a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT yujiexu a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT ruhongzhou a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT zhifangchai a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT shuaowang a32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT xiaomeiwang 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT xingdai 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT censhi 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT jianmeiwan 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT markasilver 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT linjuanzhang 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT lanhuachen 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT xuanyi 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT bizhengchen 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT duozhang 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT kaiyang 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT juandiwu 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT jianqiangwang 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT yujiexu 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT ruhongzhou 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT zhifangchai 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo AT shuaowang 32hydroxypyridinonebaseddecorporationagentthatremovesuraniumfrombonesinvivo
_version_	1718386515019563008

A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo

Ejemplares similares