An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer.

An adeno-associated virus-based intracellular sensor of pathological nuclear factor-κB activation for disease-inducible gene transfer.

Stimulation of resident cells by NF-κB activating cytokines is a central element of inflammatory and degenerative disorders of the central nervous system (CNS). This disease-mediated NF-κB activation could be used to drive transgene expression selectively in affected cells, using adeno-associated vi...

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Autores principales: Abdelwahed Chtarto, Olivier Bockstael, Elias Gebara, Katia Vermoesen, Catherine Melas, Catherine Pythoud, Marc Levivier, Olivier De Witte, Ruth Luthi-Carter, Ralph Clinkers, Liliane Tenenbaum
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/0f6019a6b6fb4efd9ffa751341864edc
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