Hypertension and obstructive sleep apnea

Hypertension and obstructive sleep apnea

Craig L Phillips,1–3 Denise M O'Driscoll4,51Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia; 2National Health and Medical Research Council Center for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research,...

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Autores principales: Phillips CL, O'Driscoll DM
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
Materias:
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
Acceso en línea:https://doaj.org/article/0f6126c2412d4373856c20559eafd830
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spelling oai:doaj.org-article:0f6126c2412d4373856c20559eafd8302021-12-02T08:44:19ZHypertension and obstructive sleep apnea1179-1608https://doaj.org/article/0f6126c2412d4373856c20559eafd8302013-05-01T00:00:00Zhttp://www.dovepress.com/hypertension-and-obstructive-sleep-apnea-a13018https://doaj.org/toc/1179-1608Craig L Phillips,1–3 Denise M O'Driscoll4,51Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia; 2National Health and Medical Research Council Center for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia; 3Discipline of Sleep Medicine, Sydney Medical School, University of Sydney, Sydney, Australia; 4Monash Lung and Sleep, Monash Medical Centre, Monash University, Melbourne, Australia; 5Department of Medicine, Southern Clinical School, Monash University, Melbourne, AustraliaAbstract: Obstructive sleep apnea (OSA) is increasingly being recognized as a major health burden with strong focus on the associated cardiovascular risk. Studies from the last two decades have provided strong evidence for a causal role of OSA in the development of systemic hypertension. The acute physiological changes that occur during apnea promote nocturnal hypertension and may lead to the development of sustained daytime hypertension via the pathways of sympathetic activation, inflammation, oxidative stress, and endothelial dysfunction. This review will focus on the acute hemodynamic disturbances and associated intermittent hypoxia that characterize OSA and the potential pathophysiological mechanisms responsible for the development of hypertension in OSA. In addition the epidemiology of OSA and hypertension, as well as the role of treatment of OSA, in improving blood pressure control will be examined.Keywords: obstructive sleep apnea, hypertension, intermittent hypoxia, ambulatory blood pressure, sympathetic activationPhillips CLO'Driscoll DMDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2013, Iss default, Pp 43-52 (2013)
institution DOAJ
collection DOAJ
language EN
topic Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
spellingShingle Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
Phillips CL
O'Driscoll DM
Hypertension and obstructive sleep apnea
description Craig L Phillips,1–3 Denise M O'Driscoll4,51Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, Australia; 2National Health and Medical Research Council Center for Integrated Research and Understanding of Sleep, Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia; 3Discipline of Sleep Medicine, Sydney Medical School, University of Sydney, Sydney, Australia; 4Monash Lung and Sleep, Monash Medical Centre, Monash University, Melbourne, Australia; 5Department of Medicine, Southern Clinical School, Monash University, Melbourne, AustraliaAbstract: Obstructive sleep apnea (OSA) is increasingly being recognized as a major health burden with strong focus on the associated cardiovascular risk. Studies from the last two decades have provided strong evidence for a causal role of OSA in the development of systemic hypertension. The acute physiological changes that occur during apnea promote nocturnal hypertension and may lead to the development of sustained daytime hypertension via the pathways of sympathetic activation, inflammation, oxidative stress, and endothelial dysfunction. This review will focus on the acute hemodynamic disturbances and associated intermittent hypoxia that characterize OSA and the potential pathophysiological mechanisms responsible for the development of hypertension in OSA. In addition the epidemiology of OSA and hypertension, as well as the role of treatment of OSA, in improving blood pressure control will be examined.Keywords: obstructive sleep apnea, hypertension, intermittent hypoxia, ambulatory blood pressure, sympathetic activation
format article
author Phillips CL
O'Driscoll DM
author_facet Phillips CL
O'Driscoll DM
author_sort Phillips CL
title Hypertension and obstructive sleep apnea
title_short Hypertension and obstructive sleep apnea
title_full Hypertension and obstructive sleep apnea
title_fullStr Hypertension and obstructive sleep apnea
title_full_unstemmed Hypertension and obstructive sleep apnea
title_sort hypertension and obstructive sleep apnea
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/0f6126c2412d4373856c20559eafd830
work_keys_str_mv AT phillipscl hypertensionandobstructivesleepapnea
AT oamp39driscolldm hypertensionandobstructivesleepapnea
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