TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

Changes in ECM are of predictive value in pancreatic and colorectal cancer prognosis. Here, the authors perform a pan-cancer analysis and find a subset of ECM genes that is linked to TGF-β signalling signature and is correlated with immunotherapy failure.

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Autores principales:	Ankur Chakravarthy, Lubaba Khan, Nathan Peter Bensler, Pinaki Bose, Daniel D. De Carvalho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f6644ecb6fb477fb4de336f46f9241d
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spelling	oai:doaj.org-article:0f6644ecb6fb477fb4de336f46f9241d2021-12-02T16:56:43ZTGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure10.1038/s41467-018-06654-82041-1723https://doaj.org/article/0f6644ecb6fb477fb4de336f46f9241d2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06654-8https://doaj.org/toc/2041-1723Changes in ECM are of predictive value in pancreatic and colorectal cancer prognosis. Here, the authors perform a pan-cancer analysis and find a subset of ECM genes that is linked to TGF-β signalling signature and is correlated with immunotherapy failure.Ankur ChakravarthyLubaba KhanNathan Peter BenslerPinaki BoseDaniel D. De CarvalhoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ankur Chakravarthy Lubaba Khan Nathan Peter Bensler Pinaki Bose Daniel D. De Carvalho TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
description	Changes in ECM are of predictive value in pancreatic and colorectal cancer prognosis. Here, the authors perform a pan-cancer analysis and find a subset of ECM genes that is linked to TGF-β signalling signature and is correlated with immunotherapy failure.
format	article
author	Ankur Chakravarthy Lubaba Khan Nathan Peter Bensler Pinaki Bose Daniel D. De Carvalho
author_facet	Ankur Chakravarthy Lubaba Khan Nathan Peter Bensler Pinaki Bose Daniel D. De Carvalho
author_sort	Ankur Chakravarthy
title	TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
title_short	TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
title_full	TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
title_fullStr	TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
title_full_unstemmed	TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
title_sort	tgf-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/0f6644ecb6fb477fb4de336f46f9241d
work_keys_str_mv	AT ankurchakravarthy tgfbassociatedextracellularmatrixgeneslinkcancerassociatedfibroblaststoimmuneevasionandimmunotherapyfailure AT lubabakhan tgfbassociatedextracellularmatrixgeneslinkcancerassociatedfibroblaststoimmuneevasionandimmunotherapyfailure AT nathanpeterbensler tgfbassociatedextracellularmatrixgeneslinkcancerassociatedfibroblaststoimmuneevasionandimmunotherapyfailure AT pinakibose tgfbassociatedextracellularmatrixgeneslinkcancerassociatedfibroblaststoimmuneevasionandimmunotherapyfailure AT danielddecarvalho tgfbassociatedextracellularmatrixgeneslinkcancerassociatedfibroblaststoimmuneevasionandimmunotherapyfailure
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TGF-β-associated extracellular matrix genes link cancer-associated fibroblasts to immune evasion and immunotherapy failure

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