Activity and potential role of licofelone in the management of osteoarthritis

Arrigo FG Cicero, Luca Laghi“D. Campanacci” Clinical Medicine & Applied Biotechnology Dept. Sant’Orsola-Malpighi Hospital – University of Bologna Via Massarenti, 9, 40138 Bologna, ItalyAbstract: Osteoarthritis is the most common form of arthritis. It i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Arrigo FG Cicero, Luca Laghi
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/0f670323e6c1404e929fb83ba1578ce1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0f670323e6c1404e929fb83ba1578ce1
record_format	dspace
spelling	oai:doaj.org-article:0f670323e6c1404e929fb83ba1578ce12021-12-02T09:41:03ZActivity and potential role of licofelone in the management of osteoarthritis1178-1998https://doaj.org/article/0f670323e6c1404e929fb83ba1578ce12007-04-01T00:00:00Zhttps://www.dovepress.com/activity-and-potential-role-of-licofelone-in-the-management-of-osteoar-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Arrigo FG Cicero, Luca Laghi“D. Campanacci” Clinical Medicine & Applied Biotechnology Dept. Sant’Orsola-Malpighi Hospital – University of Bologna Via Massarenti, 9, 40138 Bologna, ItalyAbstract: Osteoarthritis is the most common form of arthritis. It is a progressive joint disease associated with aging. It may be found in the knees, hips, or other joints. It is estimated that costs associated with osteoarthritis exceed 2% of the gross national product in developed countries. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a mainstay in the treatment of inflammatory disease and are among the most widely used drugs worldwide. The main limitation in using NSAIDs consists in their side-effects, including gastrointestinal ulcerogenic activity and bronchospasm. The mechanism of action of these drugs is attributed to the inhibition of cyclooxygenase (COX), and, consequently, the conversion of arachidonic acid into prostaglandins. It is hypothesized that the undesirable side-effects of NSAIDs are due to the inhibition of COX-1 (constitutive isoform), whereas the beneficial effects are related to the inhibition of COX-2 (inducible isoform). Arachidonic acid can also be converted to leukotrienes (LTs) by the action of 5-lipoxygenase (5-LOX). Licofelone, a LOX/COX competitive inhibitor, decreases the production of proinflammatory leukotrienes and prostaglandins (which are involved in the pathophysiology of osteoarthritis and in gastrointestinal (GI) damage induced by NSAIDs) and has the potential to combine good analgesic and anti-inflammatory effects with excellent GI tolerability. Preliminary data with this drug seem promising, but further well-designed clinical trials of this agent in the elderly will be necessary before a final evaluation is possible.Keywords: LOX/COX inhibitor, Licofelone, leukotrienes, osteoarthritis, nonsteroidal anti-inflammatory drugsArrigo FG CiceroLuca LaghiDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 73-79 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Arrigo FG Cicero Luca Laghi Activity and potential role of licofelone in the management of osteoarthritis
description	Arrigo FG Cicero, Luca Laghi“D. Campanacci” Clinical Medicine & Applied Biotechnology Dept. Sant’Orsola-Malpighi Hospital – University of Bologna Via Massarenti, 9, 40138 Bologna, ItalyAbstract: Osteoarthritis is the most common form of arthritis. It is a progressive joint disease associated with aging. It may be found in the knees, hips, or other joints. It is estimated that costs associated with osteoarthritis exceed 2% of the gross national product in developed countries. Nonsteroidal anti-inflammatory drugs (NSAIDs) are a mainstay in the treatment of inflammatory disease and are among the most widely used drugs worldwide. The main limitation in using NSAIDs consists in their side-effects, including gastrointestinal ulcerogenic activity and bronchospasm. The mechanism of action of these drugs is attributed to the inhibition of cyclooxygenase (COX), and, consequently, the conversion of arachidonic acid into prostaglandins. It is hypothesized that the undesirable side-effects of NSAIDs are due to the inhibition of COX-1 (constitutive isoform), whereas the beneficial effects are related to the inhibition of COX-2 (inducible isoform). Arachidonic acid can also be converted to leukotrienes (LTs) by the action of 5-lipoxygenase (5-LOX). Licofelone, a LOX/COX competitive inhibitor, decreases the production of proinflammatory leukotrienes and prostaglandins (which are involved in the pathophysiology of osteoarthritis and in gastrointestinal (GI) damage induced by NSAIDs) and has the potential to combine good analgesic and anti-inflammatory effects with excellent GI tolerability. Preliminary data with this drug seem promising, but further well-designed clinical trials of this agent in the elderly will be necessary before a final evaluation is possible.Keywords: LOX/COX inhibitor, Licofelone, leukotrienes, osteoarthritis, nonsteroidal anti-inflammatory drugs
format	article
author	Arrigo FG Cicero Luca Laghi
author_facet	Arrigo FG Cicero Luca Laghi
author_sort	Arrigo FG Cicero
title	Activity and potential role of licofelone in the management of osteoarthritis
title_short	Activity and potential role of licofelone in the management of osteoarthritis
title_full	Activity and potential role of licofelone in the management of osteoarthritis
title_fullStr	Activity and potential role of licofelone in the management of osteoarthritis
title_full_unstemmed	Activity and potential role of licofelone in the management of osteoarthritis
title_sort	activity and potential role of licofelone in the management of osteoarthritis
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/0f670323e6c1404e929fb83ba1578ce1
work_keys_str_mv	AT arrigofgcicero activityandpotentialroleoflicofeloneinthemanagementofosteoarthritis AT lucalaghi activityandpotentialroleoflicofeloneinthemanagementofosteoarthritis
_version_	1718398047409405952

Activity and potential role of licofelone in the management of osteoarthritis

Ejemplares similares