Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus

Iman M Eissa, Ghada A Nassar, Shaimaa A Arfeen, Ahmed A Dahab Department of Ophthalmology, Cairo University, Giza, EgyptCorrespondence: Ahmed A DahabCairo University, 27 Madinat Al-Mabouthin, Giza, EgyptTel +966559231865Email dr.adahab@yahoo.comPurpose: To evaluate the corneal pachymetric and topogr...

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Autores principales:	Eissa IM, Nassar GA, Arfeen SA, Dahab AA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cornea corneal pachymetry corneal topography sledai score systemic lupus erythematosus. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0f6898944f964cd4a16899402ca9085f
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spelling	oai:doaj.org-article:0f6898944f964cd4a16899402ca9085f2021-12-02T10:46:14ZEvaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus1177-5483https://doaj.org/article/0f6898944f964cd4a16899402ca9085f2020-02-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-central-and-peripheral-corneal-thicknesses-in-patients-w-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Iman M Eissa, Ghada A Nassar, Shaimaa A Arfeen, Ahmed A Dahab Department of Ophthalmology, Cairo University, Giza, EgyptCorrespondence: Ahmed A DahabCairo University, 27 Madinat Al-Mabouthin, Giza, EgyptTel +966559231865Email dr.adahab@yahoo.comPurpose: To evaluate the corneal pachymetric and topographic parameters of systemic Lupus Erythematosus (SLE) patients using Dual Scheimpflug Imaging.Methods: This observational cross-sectional controlled study included the right eye of 30 SLE patients and 30 age-matched controls. Corneal measurements were acquired by dual Scheimpflug imaging including anterior and posterior corneal curvatures, central, mid-peripheral corneal thickness (measured at the 5 mm zone) and peripheral pachymetry (measured at the 7 mm zone). SLE disease activity index (SLEDAI) was calculated and correlated with corneal pachymetry.Results: SLE patients had significantly thicker corneal periphery than controls. Mean central corneal pachymetry was 530.4± 27.3 microns (SD) in SLE and 547.5± 31.5 microns (SD) in control group, p = 0.032. The corneal periphery – except superiorly – was significantly thicker in SLE patients than controls (p ˂0.001). Nasal peripheral corneal thickness positively correlated with disease activity index SLEDAI (p=0.03).Conclusion: SLE patients present with thicker corneal periphery than controls characteristically sparing the superior quadrant. Possible corneal photosensitivity leading to peripheral immune complex deposition as well as flatter posterior corneal surface at the periphery are proposed explanations for these findings.Keywords: cornea, corneal pachymetry, corneal topography, SLEDAI score, systemic lupus erythematosusEissa IMNassar GAArfeen SADahab AADove Medical Pressarticlecorneacorneal pachymetrycorneal topographysledai scoresystemic lupus erythematosus.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 589-595 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cornea corneal pachymetry corneal topography sledai score systemic lupus erythematosus. Ophthalmology RE1-994
spellingShingle	cornea corneal pachymetry corneal topography sledai score systemic lupus erythematosus. Ophthalmology RE1-994 Eissa IM Nassar GA Arfeen SA Dahab AA Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
description	Iman M Eissa, Ghada A Nassar, Shaimaa A Arfeen, Ahmed A Dahab Department of Ophthalmology, Cairo University, Giza, EgyptCorrespondence: Ahmed A DahabCairo University, 27 Madinat Al-Mabouthin, Giza, EgyptTel +966559231865Email dr.adahab@yahoo.comPurpose: To evaluate the corneal pachymetric and topographic parameters of systemic Lupus Erythematosus (SLE) patients using Dual Scheimpflug Imaging.Methods: This observational cross-sectional controlled study included the right eye of 30 SLE patients and 30 age-matched controls. Corneal measurements were acquired by dual Scheimpflug imaging including anterior and posterior corneal curvatures, central, mid-peripheral corneal thickness (measured at the 5 mm zone) and peripheral pachymetry (measured at the 7 mm zone). SLE disease activity index (SLEDAI) was calculated and correlated with corneal pachymetry.Results: SLE patients had significantly thicker corneal periphery than controls. Mean central corneal pachymetry was 530.4± 27.3 microns (SD) in SLE and 547.5± 31.5 microns (SD) in control group, p = 0.032. The corneal periphery – except superiorly – was significantly thicker in SLE patients than controls (p ˂0.001). Nasal peripheral corneal thickness positively correlated with disease activity index SLEDAI (p=0.03).Conclusion: SLE patients present with thicker corneal periphery than controls characteristically sparing the superior quadrant. Possible corneal photosensitivity leading to peripheral immune complex deposition as well as flatter posterior corneal surface at the periphery are proposed explanations for these findings.Keywords: cornea, corneal pachymetry, corneal topography, SLEDAI score, systemic lupus erythematosus
format	article
author	Eissa IM Nassar GA Arfeen SA Dahab AA
author_facet	Eissa IM Nassar GA Arfeen SA Dahab AA
author_sort	Eissa IM
title	Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
title_short	Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
title_full	Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
title_fullStr	Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
title_full_unstemmed	Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus
title_sort	evaluation of central and peripheral corneal thicknesses in patients with systemic lupus erythematosus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/0f6898944f964cd4a16899402ca9085f
work_keys_str_mv	AT eissaim evaluationofcentralandperipheralcornealthicknessesinpatientswithsystemiclupuserythematosus AT nassarga evaluationofcentralandperipheralcornealthicknessesinpatientswithsystemiclupuserythematosus AT arfeensa evaluationofcentralandperipheralcornealthicknessesinpatientswithsystemiclupuserythematosus AT dahabaa evaluationofcentralandperipheralcornealthicknessesinpatientswithsystemiclupuserythematosus
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Evaluation of Central and Peripheral Corneal Thicknesses in Patients with Systemic Lupus Erythematosus

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