Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge

Summary: Neurovascular coupling (NVC), the process that links neuronal activity to cerebral blood flow changes, has been mainly studied in superficial brain areas, namely the neocortex. Whether the conventional, rapid, and spatially restricted NVC response can be generalized to deeper and functional...

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Autores principales:	Ranjan K. Roy, Ferdinand Althammer, Alexander J. Seymour, Wenting Du, Vinicia C. Biancardi, Jordan P. Hamm, Jessica A. Filosa, Colin H. Brown, Javier E. Stern
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	parenchymal arteriole vasoconstriction dendritic release hypoxia Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0f6ae9760d764ee28bc97bde1ff6691a
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spelling	oai:doaj.org-article:0f6ae9760d764ee28bc97bde1ff6691a2021-11-04T04:29:14ZInverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge2211-124710.1016/j.celrep.2021.109925https://doaj.org/article/0f6ae9760d764ee28bc97bde1ff6691a2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221112472101398Xhttps://doaj.org/toc/2211-1247Summary: Neurovascular coupling (NVC), the process that links neuronal activity to cerebral blood flow changes, has been mainly studied in superficial brain areas, namely the neocortex. Whether the conventional, rapid, and spatially restricted NVC response can be generalized to deeper and functionally diverse brain regions remains unknown. Implementing an approach for in vivo two-photon imaging from the ventral surface of the brain, we show that a systemic homeostatic challenge, acute salt loading, progressively increases hypothalamic vasopressin (VP) neuronal firing and evokes a vasoconstriction that reduces local blood flow. Vasoconstrictions are blocked by topical application of a VP receptor antagonist or tetrodotoxin, supporting mediation by activity-dependent, dendritically released VP. Salt-induced inverse NVC results in a local hypoxic microenvironment, which evokes positive feedback excitation of VP neurons. Our results reveal a physiological mechanism by which inverse NVC responses regulate systemic homeostasis, further supporting the notion of brain heterogeneity in NVC responses.Ranjan K. RoyFerdinand AlthammerAlexander J. SeymourWenting DuVinicia C. BiancardiJordan P. HammJessica A. FilosaColin H. BrownJavier E. SternElsevierarticleparenchymal arteriolevasoconstrictiondendritic releasehypoxiaBiology (General)QH301-705.5ENCell Reports, Vol 37, Iss 5, Pp 109925- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	parenchymal arteriole vasoconstriction dendritic release hypoxia Biology (General) QH301-705.5
spellingShingle	parenchymal arteriole vasoconstriction dendritic release hypoxia Biology (General) QH301-705.5 Ranjan K. Roy Ferdinand Althammer Alexander J. Seymour Wenting Du Vinicia C. Biancardi Jordan P. Hamm Jessica A. Filosa Colin H. Brown Javier E. Stern Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge
description	Summary: Neurovascular coupling (NVC), the process that links neuronal activity to cerebral blood flow changes, has been mainly studied in superficial brain areas, namely the neocortex. Whether the conventional, rapid, and spatially restricted NVC response can be generalized to deeper and functionally diverse brain regions remains unknown. Implementing an approach for in vivo two-photon imaging from the ventral surface of the brain, we show that a systemic homeostatic challenge, acute salt loading, progressively increases hypothalamic vasopressin (VP) neuronal firing and evokes a vasoconstriction that reduces local blood flow. Vasoconstrictions are blocked by topical application of a VP receptor antagonist or tetrodotoxin, supporting mediation by activity-dependent, dendritically released VP. Salt-induced inverse NVC results in a local hypoxic microenvironment, which evokes positive feedback excitation of VP neurons. Our results reveal a physiological mechanism by which inverse NVC responses regulate systemic homeostasis, further supporting the notion of brain heterogeneity in NVC responses.
format	article
author	Ranjan K. Roy Ferdinand Althammer Alexander J. Seymour Wenting Du Vinicia C. Biancardi Jordan P. Hamm Jessica A. Filosa Colin H. Brown Javier E. Stern
author_facet	Ranjan K. Roy Ferdinand Althammer Alexander J. Seymour Wenting Du Vinicia C. Biancardi Jordan P. Hamm Jessica A. Filosa Colin H. Brown Javier E. Stern
author_sort	Ranjan K. Roy
title	Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge
title_short	Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge
title_full	Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge
title_fullStr	Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge
title_full_unstemmed	Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge
title_sort	inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/0f6ae9760d764ee28bc97bde1ff6691a
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Inverse neurovascular coupling contributes to positive feedback excitation of vasopressin neurons during a systemic homeostatic challenge

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