Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors

Abstract As the use of elderly kidney donors for transplantation is increasing with time, there is a need to understand which factors impact on their prognosis. No data exist on the impact of an impaired renal function (IRF) in such population. 116 kidney recipients from deceased kidney donors over...

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Autores principales:	Mehdi Maanaoui, François Provôt, Sébastien Bouyé, Arnaud Lionet, Rémi Lenain, Victor Fages, Marie Frimat, Céline Lebas, François Glowacki, Marc Hazzan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f6da832d9c849eab903e93689b0ffb9
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spelling	oai:doaj.org-article:0f6da832d9c849eab903e93689b0ffb92021-12-02T14:58:14ZImpaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors10.1038/s41598-021-91843-72045-2322https://doaj.org/article/0f6da832d9c849eab903e93689b0ffb92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91843-7https://doaj.org/toc/2045-2322Abstract As the use of elderly kidney donors for transplantation is increasing with time, there is a need to understand which factors impact on their prognosis. No data exist on the impact of an impaired renal function (IRF) in such population. 116 kidney recipients from deceased kidney donors over 70 years were included from 2005 to 2015 in a single-center retrospective study. IRF before organ procurement was defined as a serum creatinine above 1.0 mg/dl or a transient episode of oligo-anuria. Mean ages for donors and recipients were respectively 74.8 ± 3.5 and 66.7 ± 8.0. Graft survival censored for death at 5 years was of 77%. Using a multivariate analysis by Cox model, the only predictor of graft loss present in the donor was IRF before organ procurement (HR 4.2 CI95[1.8–9.7]). IRF was also associated with significant lower estimated glomerular filtration rates up to 1 year post-transplantation. By contrast, KDPI score (median of 98 [96–100]), was not associated with the risk of graft failure. Then, IRF before kidney procurement may define a risk subgroup among very-old deceased kidney donors, in whom pre-implantatory biopsies, dual kidney transplantation or calcineurin inhibitor-free immunosuppressive regimen could help to improve outcomes.Mehdi MaanaouiFrançois ProvôtSébastien BouyéArnaud LionetRémi LenainVictor FagesMarie FrimatCéline LebasFrançois GlowackiMarc HazzanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mehdi Maanaoui François Provôt Sébastien Bouyé Arnaud Lionet Rémi Lenain Victor Fages Marie Frimat Céline Lebas François Glowacki Marc Hazzan Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors
description	Abstract As the use of elderly kidney donors for transplantation is increasing with time, there is a need to understand which factors impact on their prognosis. No data exist on the impact of an impaired renal function (IRF) in such population. 116 kidney recipients from deceased kidney donors over 70 years were included from 2005 to 2015 in a single-center retrospective study. IRF before organ procurement was defined as a serum creatinine above 1.0 mg/dl or a transient episode of oligo-anuria. Mean ages for donors and recipients were respectively 74.8 ± 3.5 and 66.7 ± 8.0. Graft survival censored for death at 5 years was of 77%. Using a multivariate analysis by Cox model, the only predictor of graft loss present in the donor was IRF before organ procurement (HR 4.2 CI95[1.8–9.7]). IRF was also associated with significant lower estimated glomerular filtration rates up to 1 year post-transplantation. By contrast, KDPI score (median of 98 [96–100]), was not associated with the risk of graft failure. Then, IRF before kidney procurement may define a risk subgroup among very-old deceased kidney donors, in whom pre-implantatory biopsies, dual kidney transplantation or calcineurin inhibitor-free immunosuppressive regimen could help to improve outcomes.
format	article
author	Mehdi Maanaoui François Provôt Sébastien Bouyé Arnaud Lionet Rémi Lenain Victor Fages Marie Frimat Céline Lebas François Glowacki Marc Hazzan
author_facet	Mehdi Maanaoui François Provôt Sébastien Bouyé Arnaud Lionet Rémi Lenain Victor Fages Marie Frimat Céline Lebas François Glowacki Marc Hazzan
author_sort	Mehdi Maanaoui
title	Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors
title_short	Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors
title_full	Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors
title_fullStr	Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors
title_full_unstemmed	Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors
title_sort	impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0f6da832d9c849eab903e93689b0ffb9
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Impaired renal function before kidney procurement has a deleterious impact on allograft survival in very old deceased kidney donors

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