The 2009 H1N1 Pandemic Influenza Virus: What Next?

ABSTRACT History suggests that the 2009 pandemic H1N1 influenza virus faces extinction unless it mutates to avoid already high global population immunity. The immune escape mechanisms potentially at its disposal include antigenic drift, antigenic shift via genetic reassortment, and intrasubtypic rea...

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Autores principales:	David M. Morens, Jeffery K. Taubenberger, Anthony S. Fauci
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2010
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/0f6f34dc27da42ed99fff807c11f5956
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spelling	oai:doaj.org-article:0f6f34dc27da42ed99fff807c11f59562021-11-15T15:38:16ZThe 2009 H1N1 Pandemic Influenza Virus: What Next?10.1128/mBio.00211-102150-7511https://doaj.org/article/0f6f34dc27da42ed99fff807c11f59562010-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00211-10https://doaj.org/toc/2150-7511ABSTRACT History suggests that the 2009 pandemic H1N1 influenza virus faces extinction unless it mutates to avoid already high global population immunity. The immune escape mechanisms potentially at its disposal include antigenic drift, antigenic shift via genetic reassortment, and intrasubtypic reassortment. Going back to the late 19th century, the evolutionary histories of past pandemic viruses are examined in an effort to better understand the nature and extent of the immune pressures faced by the 2009 pandemic virus in the immediate future. While human influenza viruses have often surprised us, available evidence leads to the hope that the current pandemic virus will continue to cause low or moderate mortality rates if it does not become extinct.David M. MorensJeffery K. TaubenbergerAnthony S. FauciAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 1, Iss 4 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 David M. Morens Jeffery K. Taubenberger Anthony S. Fauci The 2009 H1N1 Pandemic Influenza Virus: What Next?
description	ABSTRACT History suggests that the 2009 pandemic H1N1 influenza virus faces extinction unless it mutates to avoid already high global population immunity. The immune escape mechanisms potentially at its disposal include antigenic drift, antigenic shift via genetic reassortment, and intrasubtypic reassortment. Going back to the late 19th century, the evolutionary histories of past pandemic viruses are examined in an effort to better understand the nature and extent of the immune pressures faced by the 2009 pandemic virus in the immediate future. While human influenza viruses have often surprised us, available evidence leads to the hope that the current pandemic virus will continue to cause low or moderate mortality rates if it does not become extinct.
format	article
author	David M. Morens Jeffery K. Taubenberger Anthony S. Fauci
author_facet	David M. Morens Jeffery K. Taubenberger Anthony S. Fauci
author_sort	David M. Morens
title	The 2009 H1N1 Pandemic Influenza Virus: What Next?
title_short	The 2009 H1N1 Pandemic Influenza Virus: What Next?
title_full	The 2009 H1N1 Pandemic Influenza Virus: What Next?
title_fullStr	The 2009 H1N1 Pandemic Influenza Virus: What Next?
title_full_unstemmed	The 2009 H1N1 Pandemic Influenza Virus: What Next?
title_sort	2009 h1n1 pandemic influenza virus: what next?
publisher	American Society for Microbiology
publishDate	2010
url	https://doaj.org/article/0f6f34dc27da42ed99fff807c11f5956
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The 2009 H1N1 Pandemic Influenza Virus: What Next?

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