BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
Most tumours associated with germline BRCA1/BRCA2 loss of function mutations respond to DNA damaging agents, however, some do not. Herein, the authors identify that a subset of breast/ovarian tumors retain a normal allele, which is associated with decreased overall survival after DNA damage-inducing...
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Nature Portfolio
2017
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oai:doaj.org-article:0f6f94b247c0462089e5fb392de747ba2021-12-02T13:24:15ZBRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers10.1038/s41467-017-00388-92041-1723https://doaj.org/article/0f6f94b247c0462089e5fb392de747ba2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00388-9https://doaj.org/toc/2041-1723Most tumours associated with germline BRCA1/BRCA2 loss of function mutations respond to DNA damaging agents, however, some do not. Herein, the authors identify that a subset of breast/ovarian tumors retain a normal allele, which is associated with decreased overall survival after DNA damage-inducing platinum chemotherapy.Kara N. MaxwellBradley WubbenhorstBrandon M. WenzDaniel De SlooverJohn PlutaLyndsey EmeryAmanda BarrettAdam A. KrayaIoannis N. AnastopoulosShun YuYuchao JiangHao ChenNancy R. ZhangNicole HackmanKurt D’AndreaRobert DaberJennifer J. D. MorrissetteNandita MitraMichael FeldmanSusan M. DomchekKatherine L. NathansonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kara N. Maxwell Bradley Wubbenhorst Brandon M. Wenz Daniel De Sloover John Pluta Lyndsey Emery Amanda Barrett Adam A. Kraya Ioannis N. Anastopoulos Shun Yu Yuchao Jiang Hao Chen Nancy R. Zhang Nicole Hackman Kurt D’Andrea Robert Daber Jennifer J. D. Morrissette Nandita Mitra Michael Feldman Susan M. Domchek Katherine L. Nathanson BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers |
| description |
Most tumours associated with germline BRCA1/BRCA2 loss of function mutations respond to DNA damaging agents, however, some do not. Herein, the authors identify that a subset of breast/ovarian tumors retain a normal allele, which is associated with decreased overall survival after DNA damage-inducing platinum chemotherapy. |
| format |
article |
| author |
Kara N. Maxwell Bradley Wubbenhorst Brandon M. Wenz Daniel De Sloover John Pluta Lyndsey Emery Amanda Barrett Adam A. Kraya Ioannis N. Anastopoulos Shun Yu Yuchao Jiang Hao Chen Nancy R. Zhang Nicole Hackman Kurt D’Andrea Robert Daber Jennifer J. D. Morrissette Nandita Mitra Michael Feldman Susan M. Domchek Katherine L. Nathanson |
| author_facet |
Kara N. Maxwell Bradley Wubbenhorst Brandon M. Wenz Daniel De Sloover John Pluta Lyndsey Emery Amanda Barrett Adam A. Kraya Ioannis N. Anastopoulos Shun Yu Yuchao Jiang Hao Chen Nancy R. Zhang Nicole Hackman Kurt D’Andrea Robert Daber Jennifer J. D. Morrissette Nandita Mitra Michael Feldman Susan M. Domchek Katherine L. Nathanson |
| author_sort |
Kara N. Maxwell |
| title |
BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers |
| title_short |
BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers |
| title_full |
BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers |
| title_fullStr |
BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers |
| title_full_unstemmed |
BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers |
| title_sort |
brca locus-specific loss of heterozygosity in germline brca1 and brca2 carriers |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/0f6f94b247c0462089e5fb392de747ba |
| work_keys_str_mv |
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