A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1+cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.

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Autores principales:	Deepak Tripathi, Sambasivan Venkatasubramanian, Satyanarayana S. Cheekatla, Padmaja Paidipally, Elwyn Welch, Amy R. Tvinnereim, Ramakrishna Vankayalapati
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f70979a3a894b3e92593ad42eeb98f0
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spelling	oai:doaj.org-article:0f70979a3a894b3e92593ad42eeb98f02021-12-02T17:33:20ZA TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice10.1038/ncomms138962041-1723https://doaj.org/article/0f70979a3a894b3e92593ad42eeb98f02016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13896https://doaj.org/toc/2041-1723Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1+cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.Deepak TripathiSambasivan VenkatasubramanianSatyanarayana S. CheekatlaPadmaja PaidipallyElwyn WelchAmy R. TvinnereimRamakrishna VankayalapatiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deepak Tripathi Sambasivan Venkatasubramanian Satyanarayana S. Cheekatla Padmaja Paidipally Elwyn Welch Amy R. Tvinnereim Ramakrishna Vankayalapati A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
description	Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1+cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.
format	article
author	Deepak Tripathi Sambasivan Venkatasubramanian Satyanarayana S. Cheekatla Padmaja Paidipally Elwyn Welch Amy R. Tvinnereim Ramakrishna Vankayalapati
author_facet	Deepak Tripathi Sambasivan Venkatasubramanian Satyanarayana S. Cheekatla Padmaja Paidipally Elwyn Welch Amy R. Tvinnereim Ramakrishna Vankayalapati
author_sort	Deepak Tripathi
title	A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_short	A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_full	A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_fullStr	A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_full_unstemmed	A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_sort	tlr9 agonist promotes il-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/0f70979a3a894b3e92593ad42eeb98f0
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A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

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