A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1+cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.

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Main Authors: Deepak Tripathi, Sambasivan Venkatasubramanian, Satyanarayana S. Cheekatla, Padmaja Paidipally, Elwyn Welch, Amy R. Tvinnereim, Ramakrishna Vankayalapati
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/0f70979a3a894b3e92593ad42eeb98f0
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spelling oai:doaj.org-article:0f70979a3a894b3e92593ad42eeb98f02021-12-02T17:33:20ZA TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice10.1038/ncomms138962041-1723https://doaj.org/article/0f70979a3a894b3e92593ad42eeb98f02016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13896https://doaj.org/toc/2041-1723Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1+cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.Deepak TripathiSambasivan VenkatasubramanianSatyanarayana S. CheekatlaPadmaja PaidipallyElwyn WelchAmy R. TvinnereimRamakrishna VankayalapatiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Deepak Tripathi
Sambasivan Venkatasubramanian
Satyanarayana S. Cheekatla
Padmaja Paidipally
Elwyn Welch
Amy R. Tvinnereim
Ramakrishna Vankayalapati
A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
description Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1+cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.
format article
author Deepak Tripathi
Sambasivan Venkatasubramanian
Satyanarayana S. Cheekatla
Padmaja Paidipally
Elwyn Welch
Amy R. Tvinnereim
Ramakrishna Vankayalapati
author_facet Deepak Tripathi
Sambasivan Venkatasubramanian
Satyanarayana S. Cheekatla
Padmaja Paidipally
Elwyn Welch
Amy R. Tvinnereim
Ramakrishna Vankayalapati
author_sort Deepak Tripathi
title A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_short A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_full A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_fullStr A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_full_unstemmed A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
title_sort tlr9 agonist promotes il-22-dependent pancreatic islet allograft survival in type 1 diabetic mice
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/0f70979a3a894b3e92593ad42eeb98f0
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