A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

A TLR9 agonist promotes IL-22-dependent pancreatic islet allograft survival in type 1 diabetic mice

Tolerance is required to prevent rejection of intrahepatic islet allografts as a potential treatment for type 1 diabetes. Here the authors show that IL-22 produced by NK1.1+cells in the liver of streptozotocin T1D model mice can drive tolerance to allografted islets.

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Autores principales: Deepak Tripathi, Sambasivan Venkatasubramanian, Satyanarayana S. Cheekatla, Padmaja Paidipally, Elwyn Welch, Amy R. Tvinnereim, Ramakrishna Vankayalapati
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/0f70979a3a894b3e92593ad42eeb98f0
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