Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography

Nauman Hashmani, Sharif Hashmani Department of Ophthalmology, Hashmanis Hospital, Karachi, Pakistan Purpose: To map and view the effects of age, gender, and axial length on seven individual retinal layers around the optic nerve head (ONH).Methods: We scanned 242 healthy patients using the Spectral...

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Autores principales:	Hashmani N, Hashmani S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Optical Coherence Tomography Retina Spectral Domain Optical Coherence Tomography OCT SD-OCT Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/0f71da30e8984f8484bac4e5dde979d9
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spelling	oai:doaj.org-article:0f71da30e8984f8484bac4e5dde979d92021-12-02T00:07:48ZThree-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography1177-5483https://doaj.org/article/0f71da30e8984f8484bac4e5dde979d92017-12-01T00:00:00Zhttps://www.dovepress.com/three-dimensional-mapping-of-peripapillary-retinal-layers-using-a-spec-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Nauman Hashmani, Sharif Hashmani Department of Ophthalmology, Hashmanis Hospital, Karachi, Pakistan Purpose: To map and view the effects of age, gender, and axial length on seven individual retinal layers around the optic nerve head (ONH).Methods: We scanned 242 healthy patients using the Spectralis spectral domain optical coherence tomography in an outpatient setting. The layers were observed on the Early Treatment Diabetic Retinopathy Study sectors using the standard Spectralis Family Acquisition Module 6.0.11.0. The center was the ONH, the inner circle (IC) was 1–3 mm away, and the outer circle (OC) was 3–6 mm away. The seven layers were retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), and retinal pigment epithelium (RPE). Additionally, we calculated the mean thickness of two combined layers: inner retinal layer (IRL) and photoreceptor layer (PL). Finally, we measured the mean of the total retinal thickness (TRT).Results: The TRT was highest at the inferior end in the IC and at the nasal end in the OC. The RPE (p<0.001) and PL (p<0.001) were thicker in males; however, the IRL (p=0.015) was thicker in females. We found that the RNFL (p<0.001, r=0.139), GCL (p<0.001, r=0.116), IPL (p=0.016, r=0.059), INL (p<0.001, r=0.104), OPL (p=0.009, r=0.064), ONL (p<0.001, r=0.157), RPE (p=0.001, r=0.079), IRL (p<0.001, r=0.190), PL (p=0.030, r=0.053), and TRT (p<0.001, r=0.191) correlated negatively with age. The axial length significantly and negatively correlated at the GCL (p=0.003, r=0.093), IPL (p=0.020, r=0.072), INL (p=0.018, r=0.073), ONL (p<0.001, r=0.110), IRL (p=0.003, r=0.092), and TRT (p=0.003, r=0.094). We found poor reproducibility in the IC; however, this was excellent in the OC.Conclusion: We found significant differences in layers according to age, gender, and axial length. Additionally, reproducibility can be improved by altering the algorithm to account for the ONH parameters. Keywords: retinal segmentation, optic nerve head, sex, age, gender, interferometry Hashmani NHashmani SDove Medical PressarticleOptical Coherence TomographyRetinaSpectral Domain Optical Coherence TomographyOCTSD-OCTOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 2191-2198 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Optical Coherence Tomography Retina Spectral Domain Optical Coherence Tomography OCT SD-OCT Ophthalmology RE1-994
spellingShingle	Optical Coherence Tomography Retina Spectral Domain Optical Coherence Tomography OCT SD-OCT Ophthalmology RE1-994 Hashmani N Hashmani S Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography
description	Nauman Hashmani, Sharif Hashmani Department of Ophthalmology, Hashmanis Hospital, Karachi, Pakistan Purpose: To map and view the effects of age, gender, and axial length on seven individual retinal layers around the optic nerve head (ONH).Methods: We scanned 242 healthy patients using the Spectralis spectral domain optical coherence tomography in an outpatient setting. The layers were observed on the Early Treatment Diabetic Retinopathy Study sectors using the standard Spectralis Family Acquisition Module 6.0.11.0. The center was the ONH, the inner circle (IC) was 1–3 mm away, and the outer circle (OC) was 3–6 mm away. The seven layers were retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), and retinal pigment epithelium (RPE). Additionally, we calculated the mean thickness of two combined layers: inner retinal layer (IRL) and photoreceptor layer (PL). Finally, we measured the mean of the total retinal thickness (TRT).Results: The TRT was highest at the inferior end in the IC and at the nasal end in the OC. The RPE (p<0.001) and PL (p<0.001) were thicker in males; however, the IRL (p=0.015) was thicker in females. We found that the RNFL (p<0.001, r=0.139), GCL (p<0.001, r=0.116), IPL (p=0.016, r=0.059), INL (p<0.001, r=0.104), OPL (p=0.009, r=0.064), ONL (p<0.001, r=0.157), RPE (p=0.001, r=0.079), IRL (p<0.001, r=0.190), PL (p=0.030, r=0.053), and TRT (p<0.001, r=0.191) correlated negatively with age. The axial length significantly and negatively correlated at the GCL (p=0.003, r=0.093), IPL (p=0.020, r=0.072), INL (p=0.018, r=0.073), ONL (p<0.001, r=0.110), IRL (p=0.003, r=0.092), and TRT (p=0.003, r=0.094). We found poor reproducibility in the IC; however, this was excellent in the OC.Conclusion: We found significant differences in layers according to age, gender, and axial length. Additionally, reproducibility can be improved by altering the algorithm to account for the ONH parameters. Keywords: retinal segmentation, optic nerve head, sex, age, gender, interferometry
format	article
author	Hashmani N Hashmani S
author_facet	Hashmani N Hashmani S
author_sort	Hashmani N
title	Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography
title_short	Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography
title_full	Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography
title_fullStr	Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography
title_full_unstemmed	Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography
title_sort	three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/0f71da30e8984f8484bac4e5dde979d9
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Three-dimensional mapping of peripapillary retinal layers using a spectral domain optical coherence tomography

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