Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

ER+ breast cancer patients treated with endocrine therapies often acquire resistance and develop metastasis. In this study, the authors demonstrate that endocrine therapies can promote the self-renewal of CD133hi/ERlodrug resistant cells with metastatic potential driven through the IL6-Notch3 axis a...

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Autores principales: Pasquale Sansone, Claudio Ceccarelli, Marjan Berishaj, Qing Chang, Vinagolu K. Rajasekhar, Fabiana Perna, Robert L. Bowman, Michele Vidone, Laura Daly, Jennifer Nnoli, Donatella Santini, Mario Taffurelli, Natalie N. C. Shih, Michael Feldman, Jun J. Mao, Christopher Colameco , Jinbo Chen, Angela DeMichele, Nicola Fabbri, John H. Healey, Monica Cricca, Giuseppe Gasparre, David Lyden, Massimiliano Bonafé, Jacqueline Bromberg
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/0f73773c836b47a9b54b97e9c2ac1634
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spelling oai:doaj.org-article:0f73773c836b47a9b54b97e9c2ac16342021-12-02T17:31:34ZSelf-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer10.1038/ncomms104422041-1723https://doaj.org/article/0f73773c836b47a9b54b97e9c2ac16342016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10442https://doaj.org/toc/2041-1723ER+ breast cancer patients treated with endocrine therapies often acquire resistance and develop metastasis. In this study, the authors demonstrate that endocrine therapies can promote the self-renewal of CD133hi/ERlodrug resistant cells with metastatic potential driven through the IL6-Notch3 axis activation.Pasquale SansoneClaudio CeccarelliMarjan BerishajQing ChangVinagolu K. RajasekharFabiana PernaRobert L. BowmanMichele VidoneLaura DalyJennifer NnoliDonatella SantiniMario TaffurelliNatalie N. C. ShihMichael FeldmanJun J. MaoChristopher Colameco Jinbo ChenAngela DeMicheleNicola FabbriJohn H. HealeyMonica CriccaGiuseppe GasparreDavid LydenMassimiliano BonaféJacqueline BrombergNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Pasquale Sansone
Claudio Ceccarelli
Marjan Berishaj
Qing Chang
Vinagolu K. Rajasekhar
Fabiana Perna
Robert L. Bowman
Michele Vidone
Laura Daly
Jennifer Nnoli
Donatella Santini
Mario Taffurelli
Natalie N. C. Shih
Michael Feldman
Jun J. Mao
Christopher Colameco 
Jinbo Chen
Angela DeMichele
Nicola Fabbri
John H. Healey
Monica Cricca
Giuseppe Gasparre
David Lyden
Massimiliano Bonafé
Jacqueline Bromberg
Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
description ER+ breast cancer patients treated with endocrine therapies often acquire resistance and develop metastasis. In this study, the authors demonstrate that endocrine therapies can promote the self-renewal of CD133hi/ERlodrug resistant cells with metastatic potential driven through the IL6-Notch3 axis activation.
format article
author Pasquale Sansone
Claudio Ceccarelli
Marjan Berishaj
Qing Chang
Vinagolu K. Rajasekhar
Fabiana Perna
Robert L. Bowman
Michele Vidone
Laura Daly
Jennifer Nnoli
Donatella Santini
Mario Taffurelli
Natalie N. C. Shih
Michael Feldman
Jun J. Mao
Christopher Colameco 
Jinbo Chen
Angela DeMichele
Nicola Fabbri
John H. Healey
Monica Cricca
Giuseppe Gasparre
David Lyden
Massimiliano Bonafé
Jacqueline Bromberg
author_facet Pasquale Sansone
Claudio Ceccarelli
Marjan Berishaj
Qing Chang
Vinagolu K. Rajasekhar
Fabiana Perna
Robert L. Bowman
Michele Vidone
Laura Daly
Jennifer Nnoli
Donatella Santini
Mario Taffurelli
Natalie N. C. Shih
Michael Feldman
Jun J. Mao
Christopher Colameco 
Jinbo Chen
Angela DeMichele
Nicola Fabbri
John H. Healey
Monica Cricca
Giuseppe Gasparre
David Lyden
Massimiliano Bonafé
Jacqueline Bromberg
author_sort Pasquale Sansone
title Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
title_short Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
title_full Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
title_fullStr Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
title_full_unstemmed Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer
title_sort self-renewal of cd133hi cells by il6/notch3 signalling regulates endocrine resistance in metastatic breast cancer
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/0f73773c836b47a9b54b97e9c2ac1634
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