Postpartum depression: psychoneuroimmunological underpinnings and treatment

George Anderson,1 Michael Maes21CRC Clincial Research Centre/Communications, Glasgow, Scotland; 2Department of Psychiatry, Chulalongkorn University, Bangkok, ThailandAbstract: Postpartum depression (PPD) is common, occurring in 10%&ndash;15% of women. Due to concerns about teratogenicity of...

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Autores principales:	Anderson G, Maes M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0f7d2b9972f049ce8cf55e9e5ce04948
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spelling	oai:doaj.org-article:0f7d2b9972f049ce8cf55e9e5ce049482021-12-02T06:23:20ZPostpartum depression: psychoneuroimmunological underpinnings and treatment1176-63281178-2021https://doaj.org/article/0f7d2b9972f049ce8cf55e9e5ce049482013-02-01T00:00:00Zhttp://www.dovepress.com/postpartum-depression-psychoneuroimmunological-underpinnings-and-treat-a12280https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021George Anderson,1 Michael Maes21CRC Clincial Research Centre/Communications, Glasgow, Scotland; 2Department of Psychiatry, Chulalongkorn University, Bangkok, ThailandAbstract: Postpartum depression (PPD) is common, occurring in 10%&ndash;15% of women. Due to concerns about teratogenicity of medications in the suckling infant, the treatment of PPD has often been restricted to psychotherapy. We review here the biological underpinnings to PPD, suggesting a powerful role for the tryptophan catabolites, indoleamine 2,3-dixoygenase, serotonin, and autoimmunity in mediating the consequences of immuno-inflammation and oxidative and nitrosative stress. It is suggested that the increased inflammatory potential, the decreases in endogenous anti-inflammatory compounds together with decreased omega-3 poly-unsaturated fatty acids, in the postnatal period cause an inflammatory environment. The latter may result in the utilization of peripheral inflammatory products, especially kynurenine, in driving the central processes producing postnatal depression. The pharmacological treatment of PPD is placed in this context, and recommendations for more refined and safer treatments are made, including the better utilization of the antidepressant, and the anti-inflammatory and antioxidant effects of melatonin.Keywords: SSRI, kynurenine, IDO, TDO, melatoninAnderson GMaes MDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 277-287 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Anderson G Maes M Postpartum depression: psychoneuroimmunological underpinnings and treatment
description	George Anderson,1 Michael Maes21CRC Clincial Research Centre/Communications, Glasgow, Scotland; 2Department of Psychiatry, Chulalongkorn University, Bangkok, ThailandAbstract: Postpartum depression (PPD) is common, occurring in 10%&ndash;15% of women. Due to concerns about teratogenicity of medications in the suckling infant, the treatment of PPD has often been restricted to psychotherapy. We review here the biological underpinnings to PPD, suggesting a powerful role for the tryptophan catabolites, indoleamine 2,3-dixoygenase, serotonin, and autoimmunity in mediating the consequences of immuno-inflammation and oxidative and nitrosative stress. It is suggested that the increased inflammatory potential, the decreases in endogenous anti-inflammatory compounds together with decreased omega-3 poly-unsaturated fatty acids, in the postnatal period cause an inflammatory environment. The latter may result in the utilization of peripheral inflammatory products, especially kynurenine, in driving the central processes producing postnatal depression. The pharmacological treatment of PPD is placed in this context, and recommendations for more refined and safer treatments are made, including the better utilization of the antidepressant, and the anti-inflammatory and antioxidant effects of melatonin.Keywords: SSRI, kynurenine, IDO, TDO, melatonin
format	article
author	Anderson G Maes M
author_facet	Anderson G Maes M
author_sort	Anderson G
title	Postpartum depression: psychoneuroimmunological underpinnings and treatment
title_short	Postpartum depression: psychoneuroimmunological underpinnings and treatment
title_full	Postpartum depression: psychoneuroimmunological underpinnings and treatment
title_fullStr	Postpartum depression: psychoneuroimmunological underpinnings and treatment
title_full_unstemmed	Postpartum depression: psychoneuroimmunological underpinnings and treatment
title_sort	postpartum depression: psychoneuroimmunological underpinnings and treatment
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/0f7d2b9972f049ce8cf55e9e5ce04948
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Postpartum depression: psychoneuroimmunological underpinnings and treatment

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