MiRNAs as biomarkers of myocardial infarction: a meta-analysis.

<h4>Background</h4>Recent studies have demonstrated that acute myocardial infarction induces a distinctive miRNA signature, suggesting that miRNAs may serve as diagnostic markers. Although many studies have investigated the use of miRNAs in the detection of cardiac injury, some had small...

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Autores principales:	Chao Cheng, Qiang Wang, Wenjie You, Manhua Chen, Jiahong Xia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f7e64d9293242028b438b2a77da7826
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spelling	oai:doaj.org-article:0f7e64d9293242028b438b2a77da78262021-11-18T08:32:48ZMiRNAs as biomarkers of myocardial infarction: a meta-analysis.1932-620310.1371/journal.pone.0088566https://doaj.org/article/0f7e64d9293242028b438b2a77da78262014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24533109/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recent studies have demonstrated that acute myocardial infarction induces a distinctive miRNA signature, suggesting that miRNAs may serve as diagnostic markers. Although many studies have investigated the use of miRNAs in the detection of cardiac injury, some had small sample sizes (<100 patients) or reported different results for the same miRNA. Here, the role of circulating miRNAs for use as biomarkers of myocardial infarction is summarized and analyzed.<h4>Methods and results</h4>Medline, SCI, Embase, and Cochrane databases were searched up to January 2013 for studies that evaluated associations between miRNAs and myocardial infarction. Relevant publications were identified by searching for combinations of "myocardial infarction," "miRNAs," and their synonyms. Methodological quality was scored using a standardized list of criteria, and diagnostic performance was assessed using estimates of test sensitivity and specificity. These values were summarized using summary receiver-operating characteristic curves. Nineteen studies met the inclusion criteria: 15 studies reported sensitivity, specificity, and AUC, but 4 studies did not. Total miRNAs: sensitivity: 0.78 (95%CI: 0.77-0.80; P = 0.0000); specificity: 0.82 (95%CI: 0.80-0.83; P = 0.0000). miR-499: sensitivity: 0.88 (95%CI:0.86-0.90; P = 0.0000); specificity: 0.87 (95%CI:0.84-0.90; P = 0.0000). miR-1: sensitivity: 0.63 (95%CI:0.59-0.66; P = 0.0000); specificity: 0.76 (95%CI:0.71-0.80; P = 0.0000). miR-133a: sensitivity: 0.89 (95%CI:0.83-0.94; P = 0.0047); specificity: 0.87 (95%CI:0.79-0.92; P = 0.0262). miR-208b: sensitivity: 0.78 (95%CI:0.76-0.81; P = 0.0581); specificity: 0.88 (95%CI:0.84-0.91; P = 0.0000). The correlation between miRNAs and other diagnostic biomarkers of myocardial infarction was obvious.<h4>Conclusion</h4>MiRNAs, especially miR-499 and miR-133a, may be suitable for use as diagnostic biomarkers of myocardial infarction.Chao ChengQiang WangWenjie YouManhua ChenJiahong XiaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88566 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chao Cheng Qiang Wang Wenjie You Manhua Chen Jiahong Xia MiRNAs as biomarkers of myocardial infarction: a meta-analysis.
description	<h4>Background</h4>Recent studies have demonstrated that acute myocardial infarction induces a distinctive miRNA signature, suggesting that miRNAs may serve as diagnostic markers. Although many studies have investigated the use of miRNAs in the detection of cardiac injury, some had small sample sizes (<100 patients) or reported different results for the same miRNA. Here, the role of circulating miRNAs for use as biomarkers of myocardial infarction is summarized and analyzed.<h4>Methods and results</h4>Medline, SCI, Embase, and Cochrane databases were searched up to January 2013 for studies that evaluated associations between miRNAs and myocardial infarction. Relevant publications were identified by searching for combinations of "myocardial infarction," "miRNAs," and their synonyms. Methodological quality was scored using a standardized list of criteria, and diagnostic performance was assessed using estimates of test sensitivity and specificity. These values were summarized using summary receiver-operating characteristic curves. Nineteen studies met the inclusion criteria: 15 studies reported sensitivity, specificity, and AUC, but 4 studies did not. Total miRNAs: sensitivity: 0.78 (95%CI: 0.77-0.80; P = 0.0000); specificity: 0.82 (95%CI: 0.80-0.83; P = 0.0000). miR-499: sensitivity: 0.88 (95%CI:0.86-0.90; P = 0.0000); specificity: 0.87 (95%CI:0.84-0.90; P = 0.0000). miR-1: sensitivity: 0.63 (95%CI:0.59-0.66; P = 0.0000); specificity: 0.76 (95%CI:0.71-0.80; P = 0.0000). miR-133a: sensitivity: 0.89 (95%CI:0.83-0.94; P = 0.0047); specificity: 0.87 (95%CI:0.79-0.92; P = 0.0262). miR-208b: sensitivity: 0.78 (95%CI:0.76-0.81; P = 0.0581); specificity: 0.88 (95%CI:0.84-0.91; P = 0.0000). The correlation between miRNAs and other diagnostic biomarkers of myocardial infarction was obvious.<h4>Conclusion</h4>MiRNAs, especially miR-499 and miR-133a, may be suitable for use as diagnostic biomarkers of myocardial infarction.
format	article
author	Chao Cheng Qiang Wang Wenjie You Manhua Chen Jiahong Xia
author_facet	Chao Cheng Qiang Wang Wenjie You Manhua Chen Jiahong Xia
author_sort	Chao Cheng
title	MiRNAs as biomarkers of myocardial infarction: a meta-analysis.
title_short	MiRNAs as biomarkers of myocardial infarction: a meta-analysis.
title_full	MiRNAs as biomarkers of myocardial infarction: a meta-analysis.
title_fullStr	MiRNAs as biomarkers of myocardial infarction: a meta-analysis.
title_full_unstemmed	MiRNAs as biomarkers of myocardial infarction: a meta-analysis.
title_sort	mirnas as biomarkers of myocardial infarction: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/0f7e64d9293242028b438b2a77da7826
work_keys_str_mv	AT chaocheng mirnasasbiomarkersofmyocardialinfarctionametaanalysis AT qiangwang mirnasasbiomarkersofmyocardialinfarctionametaanalysis AT wenjieyou mirnasasbiomarkersofmyocardialinfarctionametaanalysis AT manhuachen mirnasasbiomarkersofmyocardialinfarctionametaanalysis AT jiahongxia mirnasasbiomarkersofmyocardialinfarctionametaanalysis
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MiRNAs as biomarkers of myocardial infarction: a meta-analysis.

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