Timed daily exercise remodels circadian rhythms in mice

Using mice with disrupted neuropeptide signaling, Hughes et al. show that daily scheduled voluntary exercise (SVE) promotes suprachiasmatic nuclei (SCN) clock cell synchrony and robust 24 h rhythms in behavior. This study suggests the potential utility of regular exercise as a non-invasive intervent...

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Autores principales: Alun Thomas Lloyd Hughes, Rayna Eve Samuels, Beatriz Baño-Otálora, Mino David Charles Belle, Sven Wegner, Clare Guilding, Rebecca Catrin Northeast, Andrew Stewart Irvine Loudon, John Gigg, Hugh David Piggins
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0f7f59e65316410d88152cdba79bd9cc
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Sumario:Using mice with disrupted neuropeptide signaling, Hughes et al. show that daily scheduled voluntary exercise (SVE) promotes suprachiasmatic nuclei (SCN) clock cell synchrony and robust 24 h rhythms in behavior. This study suggests the potential utility of regular exercise as a non-invasive intervention for the elderly or mentally ill, where circadian rhythms can be poorly aligned to the external world.