Associations of Hypothyroxinemia With Risk of Preeclampsia–Eclampsia and Gestational Hypertension
ObjectiveTo investigate the association between hypothyroxinemia and the risk of preeclampsia–eclampsia and gestational hypertension.DesignHistorical cohort study.MethodsThe study included pregnant individuals who delivered live-born singletons and had at least one thyroid function assessment during...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:0f80f24ab68b4256b3163fa1b33f66272021-11-04T09:12:24ZAssociations of Hypothyroxinemia With Risk of Preeclampsia–Eclampsia and Gestational Hypertension1664-239210.3389/fendo.2021.777152https://doaj.org/article/0f80f24ab68b4256b3163fa1b33f66272021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.777152/fullhttps://doaj.org/toc/1664-2392ObjectiveTo investigate the association between hypothyroxinemia and the risk of preeclampsia–eclampsia and gestational hypertension.DesignHistorical cohort study.MethodsThe study included pregnant individuals who delivered live-born singletons and had at least one thyroid function assessment during pregnancy at a tertiary hospital. Hypothyroxinemia was defined as thyroid-stimulating hormone (TSH) levels within the normal reference range and free thyroxine (FT4) levels lower than the tenth percentile. Risk ratios (RRs) with 95% confidence intervals (95% CIs) for preeclampsia–eclampsia and gestational hypertension between women with and without a diagnosis of hypothyroxinemia during pregnancy were estimated using a generalized estimating equation model.ResultsA total of 59,463 women with live-born singletons were included in the analysis. Logistic regression models with restricted cubic spline suggested that there was a U-shaped association between FT4 levels and preeclampsia–eclampsia risk. Compared with euthyroid women, those with hypothyroxinemia had an increased risk of preeclampsia–eclampsia (RR = 1.16, 95% CI: 1.02–1.31), and the risk increased with the increasing severity of hypothyroxinemia (p for trend < 0.001). Moreover, persistent hypothyroxinemia from the first to second trimesters was associated with an increased risk of preeclampsia–eclampsia (RR = 1.37, 95% CI: 1.03–1.83), especially for women with severe hypothyroxinemia (RR = 1.70, 95% CI: 1.12–2.58). In contrast, there was no association between hypothyroxinemia and gestational hypertension.ConclusionOur study suggested that hypothyroxinemia was only associated with an increased risk of preeclampsia–eclampsia, especially in women with persistent hypothyroxinemia in the first half of pregnancy. Analyses of the associated risk of gestational hypertension with hypothyroxinemia were not significant.Xiujuan SuYang LiuGuohua LiXiaosong LiuShijia HuangTao DuanQiaoling DuFrontiers Media S.A.articlehypothyroxinemiacohort studyhypertension disorders during pregnancypreeclampsia–eclampsiagestational hypertension (GH)Diseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021) |
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| collection |
DOAJ |
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EN |
| topic |
hypothyroxinemia cohort study hypertension disorders during pregnancy preeclampsia–eclampsia gestational hypertension (GH) Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
| spellingShingle |
hypothyroxinemia cohort study hypertension disorders during pregnancy preeclampsia–eclampsia gestational hypertension (GH) Diseases of the endocrine glands. Clinical endocrinology RC648-665 Xiujuan Su Yang Liu Guohua Li Xiaosong Liu Shijia Huang Tao Duan Qiaoling Du Associations of Hypothyroxinemia With Risk of Preeclampsia–Eclampsia and Gestational Hypertension |
| description |
ObjectiveTo investigate the association between hypothyroxinemia and the risk of preeclampsia–eclampsia and gestational hypertension.DesignHistorical cohort study.MethodsThe study included pregnant individuals who delivered live-born singletons and had at least one thyroid function assessment during pregnancy at a tertiary hospital. Hypothyroxinemia was defined as thyroid-stimulating hormone (TSH) levels within the normal reference range and free thyroxine (FT4) levels lower than the tenth percentile. Risk ratios (RRs) with 95% confidence intervals (95% CIs) for preeclampsia–eclampsia and gestational hypertension between women with and without a diagnosis of hypothyroxinemia during pregnancy were estimated using a generalized estimating equation model.ResultsA total of 59,463 women with live-born singletons were included in the analysis. Logistic regression models with restricted cubic spline suggested that there was a U-shaped association between FT4 levels and preeclampsia–eclampsia risk. Compared with euthyroid women, those with hypothyroxinemia had an increased risk of preeclampsia–eclampsia (RR = 1.16, 95% CI: 1.02–1.31), and the risk increased with the increasing severity of hypothyroxinemia (p for trend < 0.001). Moreover, persistent hypothyroxinemia from the first to second trimesters was associated with an increased risk of preeclampsia–eclampsia (RR = 1.37, 95% CI: 1.03–1.83), especially for women with severe hypothyroxinemia (RR = 1.70, 95% CI: 1.12–2.58). In contrast, there was no association between hypothyroxinemia and gestational hypertension.ConclusionOur study suggested that hypothyroxinemia was only associated with an increased risk of preeclampsia–eclampsia, especially in women with persistent hypothyroxinemia in the first half of pregnancy. Analyses of the associated risk of gestational hypertension with hypothyroxinemia were not significant. |
| format |
article |
| author |
Xiujuan Su Yang Liu Guohua Li Xiaosong Liu Shijia Huang Tao Duan Qiaoling Du |
| author_facet |
Xiujuan Su Yang Liu Guohua Li Xiaosong Liu Shijia Huang Tao Duan Qiaoling Du |
| author_sort |
Xiujuan Su |
| title |
Associations of Hypothyroxinemia With Risk of Preeclampsia–Eclampsia and Gestational Hypertension |
| title_short |
Associations of Hypothyroxinemia With Risk of Preeclampsia–Eclampsia and Gestational Hypertension |
| title_full |
Associations of Hypothyroxinemia With Risk of Preeclampsia–Eclampsia and Gestational Hypertension |
| title_fullStr |
Associations of Hypothyroxinemia With Risk of Preeclampsia–Eclampsia and Gestational Hypertension |
| title_full_unstemmed |
Associations of Hypothyroxinemia With Risk of Preeclampsia–Eclampsia and Gestational Hypertension |
| title_sort |
associations of hypothyroxinemia with risk of preeclampsia–eclampsia and gestational hypertension |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/0f80f24ab68b4256b3163fa1b33f6627 |
| work_keys_str_mv |
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