Identification of hepadnavirus in the sera of cats

Abstract Hepadnaviruses infect several animal species. The prototype species, human hepatitis B virus (HBV), increases the risk of liver diseases and may cause cirrhosis and hepatocellular carcinoma. Recently a novel hepadnavirus, similar to HBV, has been identified through transcriptomics studies i...

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Autores principales:	Gianvito Lanave, Paolo Capozza, Georgia Diakoudi, Cristiana Catella, Leonardo Catucci, Paola Ghergo, Fabio Stasi, Vanessa Barrs, Julia Beatty, Nicola Decaro, Canio Buonavoglia, Vito Martella, Michele Camero
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f8262f8b42946eb86d79938e398a550
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spelling	oai:doaj.org-article:0f8262f8b42946eb86d79938e398a5502021-12-02T16:08:05ZIdentification of hepadnavirus in the sera of cats10.1038/s41598-019-47175-82045-2322https://doaj.org/article/0f8262f8b42946eb86d79938e398a5502019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-47175-8https://doaj.org/toc/2045-2322Abstract Hepadnaviruses infect several animal species. The prototype species, human hepatitis B virus (HBV), increases the risk of liver diseases and may cause cirrhosis and hepatocellular carcinoma. Recently a novel hepadnavirus, similar to HBV, has been identified through transcriptomics studies in a domestic cat with large cell lymphoma in Australia. Herewith, a collection of 390 feline serum samples was screened for hepadnavirus. Overall, the virus was identified in 10.8% of the sera with a significantly higher prevalence (17.8%) in the sera of animals with a clinical suspect of infectious disease. Upon genome sequencing, the virus was closely related (97.0% nt identity) to the prototype Australian feline virus Sydney 2016. The mean and median values of hepadnavirus in the feline sera were 1.3 × 106 and 2.1 × 104 genome copies per mL (range 3.3 × 100–2.5 × 107 genome copies per mL). For a subset of hepadnavirus-positive samples, information on the hemato-chemical parameters was available and in 10/20 animals a profile suggestive of liver damage was present. Also, in 7/10 animals with suspected hepatic disease, virus load was >104 genome copies per mL, i.e. above the threshold considered at risk of active hepatitis and liver damage for HBV.Gianvito LanavePaolo CapozzaGeorgia DiakoudiCristiana CatellaLeonardo CatucciPaola GhergoFabio StasiVanessa BarrsJulia BeattyNicola DecaroCanio BuonavogliaVito MartellaMichele CameroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-6 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gianvito Lanave Paolo Capozza Georgia Diakoudi Cristiana Catella Leonardo Catucci Paola Ghergo Fabio Stasi Vanessa Barrs Julia Beatty Nicola Decaro Canio Buonavoglia Vito Martella Michele Camero Identification of hepadnavirus in the sera of cats
description	Abstract Hepadnaviruses infect several animal species. The prototype species, human hepatitis B virus (HBV), increases the risk of liver diseases and may cause cirrhosis and hepatocellular carcinoma. Recently a novel hepadnavirus, similar to HBV, has been identified through transcriptomics studies in a domestic cat with large cell lymphoma in Australia. Herewith, a collection of 390 feline serum samples was screened for hepadnavirus. Overall, the virus was identified in 10.8% of the sera with a significantly higher prevalence (17.8%) in the sera of animals with a clinical suspect of infectious disease. Upon genome sequencing, the virus was closely related (97.0% nt identity) to the prototype Australian feline virus Sydney 2016. The mean and median values of hepadnavirus in the feline sera were 1.3 × 106 and 2.1 × 104 genome copies per mL (range 3.3 × 100–2.5 × 107 genome copies per mL). For a subset of hepadnavirus-positive samples, information on the hemato-chemical parameters was available and in 10/20 animals a profile suggestive of liver damage was present. Also, in 7/10 animals with suspected hepatic disease, virus load was >104 genome copies per mL, i.e. above the threshold considered at risk of active hepatitis and liver damage for HBV.
format	article
author	Gianvito Lanave Paolo Capozza Georgia Diakoudi Cristiana Catella Leonardo Catucci Paola Ghergo Fabio Stasi Vanessa Barrs Julia Beatty Nicola Decaro Canio Buonavoglia Vito Martella Michele Camero
author_facet	Gianvito Lanave Paolo Capozza Georgia Diakoudi Cristiana Catella Leonardo Catucci Paola Ghergo Fabio Stasi Vanessa Barrs Julia Beatty Nicola Decaro Canio Buonavoglia Vito Martella Michele Camero
author_sort	Gianvito Lanave
title	Identification of hepadnavirus in the sera of cats
title_short	Identification of hepadnavirus in the sera of cats
title_full	Identification of hepadnavirus in the sera of cats
title_fullStr	Identification of hepadnavirus in the sera of cats
title_full_unstemmed	Identification of hepadnavirus in the sera of cats
title_sort	identification of hepadnavirus in the sera of cats
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0f8262f8b42946eb86d79938e398a550
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Identification of hepadnavirus in the sera of cats

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