Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4-hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been prepared. The compounds have been c...

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Autores principales:	Sahar S. Hassan, Nidhal M. Hassan, Shaymaa Rajab Baqer, Asmaa M. saleh
Formato:	article
Lenguaje:	AR EN
Publicado:	College of Science for Women, University of Baghdad 2021
Materias:	Schiff base, Complexes of Schiff base, Biological activity, Theoretical study Science Q
Acceso en línea:	https://doaj.org/article/0f82ea4d4f9d45cd84e10a6136e86f10
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spelling	oai:doaj.org-article:0f82ea4d4f9d45cd84e10a6136e86f102021-12-04T16:12:55ZBiological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions 10.21123/bsj.2021.18.4.12692078-86652411-7986https://doaj.org/article/0f82ea4d4f9d45cd84e10a6136e86f102021-12-01T00:00:00Zhttps://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/4802https://doaj.org/toc/2078-8665https://doaj.org/toc/2411-7986 In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4-hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been prepared. The compounds have been characterized by different means such as FT-IR, UV-Vis, magnetic moment, elemental microanalyses (C.H.N), atomic absorption, and molar conductance. It is obvious when looking at the spectral study that the overall complexes obtained as monomeric structure as well as the metals center moieties are two-coordinated with octahedral geometry excepting Co complexes that existed as a tetrahedral geometry. Hyper Chem-8.0.7 program was employed, after calculating the heat of formation (ΔH°f), binding energy (ΔEb), dipole moment( µ ), and FT-IR frequencies are carried out in gas phase, the geometric shape is suggested. The compounds have been also screened for their bioactivity to antibacterial and antifungal. Sahar S. HassanNidhal M. HassanShaymaa Rajab BaqerAsmaa M. salehCollege of Science for Women, University of BaghdadarticleSchiff base, Complexes of Schiff base, Biological activity, Theoretical studyScienceQARENBaghdad Science Journal, Vol 18, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	AR EN
topic	Schiff base, Complexes of Schiff base, Biological activity, Theoretical study Science Q
spellingShingle	Schiff base, Complexes of Schiff base, Biological activity, Theoretical study Science Q Sahar S. Hassan Nidhal M. Hassan Shaymaa Rajab Baqer Asmaa M. saleh Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions
description	In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4-hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been prepared. The compounds have been characterized by different means such as FT-IR, UV-Vis, magnetic moment, elemental microanalyses (C.H.N), atomic absorption, and molar conductance. It is obvious when looking at the spectral study that the overall complexes obtained as monomeric structure as well as the metals center moieties are two-coordinated with octahedral geometry excepting Co complexes that existed as a tetrahedral geometry. Hyper Chem-8.0.7 program was employed, after calculating the heat of formation (ΔH°f), binding energy (ΔEb), dipole moment( µ ), and FT-IR frequencies are carried out in gas phase, the geometric shape is suggested. The compounds have been also screened for their bioactivity to antibacterial and antifungal.
format	article
author	Sahar S. Hassan Nidhal M. Hassan Shaymaa Rajab Baqer Asmaa M. saleh
author_facet	Sahar S. Hassan Nidhal M. Hassan Shaymaa Rajab Baqer Asmaa M. saleh
author_sort	Sahar S. Hassan
title	Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions
title_short	Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions
title_full	Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions
title_fullStr	Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions
title_full_unstemmed	Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions
title_sort	biological evaluation and theoretical study of bi-dentate ligand for amoxicillin derivative with some metal ions
publisher	College of Science for Women, University of Baghdad
publishDate	2021
url	https://doaj.org/article/0f82ea4d4f9d45cd84e10a6136e86f10
work_keys_str_mv	AT saharshassan biologicalevaluationandtheoreticalstudyofbidentateligandforamoxicillinderivativewithsomemetalions AT nidhalmhassan biologicalevaluationandtheoreticalstudyofbidentateligandforamoxicillinderivativewithsomemetalions AT shaymaarajabbaqer biologicalevaluationandtheoreticalstudyofbidentateligandforamoxicillinderivativewithsomemetalions AT asmaamsaleh biologicalevaluationandtheoreticalstudyofbidentateligandforamoxicillinderivativewithsomemetalions
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Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

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