REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS

Evaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with...

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Autores principales:	R. R. Khasanova, O. V. Voronkova, O. I. Urazova, V. V. Novitsky, A. K. Strelis, Yu. V. Stambula, A. E. Kolosova, V. A. Serebryakova, I. O. Naslednikova, O. V. Kolokolova, T. E. Budkina, N. P. Pirogova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	pumonary tuberculosis antigens lymphocytes cytokines reactivity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0f8520d5db3c4da18da6c2fc7d86cdae
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spelling	oai:doaj.org-article:0f8520d5db3c4da18da6c2fc7d86cdae2021-11-18T08:03:37ZREACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2009-1-35-40https://doaj.org/article/0f8520d5db3c4da18da6c2fc7d86cdae2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/73https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XEvaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with recombinant IL-2 and M. tuberculosis antigens. It was established that clinical course of infiltrative pulmonary tuberculosis, independently on drug sensitivity/resistance of the infectious pathogen, is accompanied by suppression of spontaneous lymphoproliferation. The levels of induced IL-2 production in drug-sensitive tuberculosis proved to be increased, whereas a reserve of IL-2-secreting reactivity of blood lymphocytes was lower than in drugresistant infection. Also, it was revealed that the level of lymphoproliferative response induced by IL-2, does not depend on clinical variant of tuberculosis, whereas stimulation of IL-2 production in blood lymphocytes is attained only in cases of drug-resistant tuberculosis variant.R. R. KhasanovaO. V. VoronkovaO. I. UrazovaV. V. NovitskyA. K. StrelisYu. V. StambulaA. E. KolosovaV. A. SerebryakovaI. O. NaslednikovaO. V. KolokolovaT. E. BudkinaN. P. PirogovaSPb RAACIarticlepumonary tuberculosisantigenslymphocytescytokinesreactivityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 1, Pp 35-40 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	pumonary tuberculosis antigens lymphocytes cytokines reactivity Immunologic diseases. Allergy RC581-607
spellingShingle	pumonary tuberculosis antigens lymphocytes cytokines reactivity Immunologic diseases. Allergy RC581-607 R. R. Khasanova O. V. Voronkova O. I. Urazova V. V. Novitsky A. K. Strelis Yu. V. Stambula A. E. Kolosova V. A. Serebryakova I. O. Naslednikova O. V. Kolokolova T. E. Budkina N. P. Pirogova REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS
description	Evaluation of proliferative and IL-2-producing activity of peripheral blood lymphocytes wasperformed, using cultural methods, in patients with drug-sensitive and drug-resistant infiltrative pulmonary tuberculosis. The cell testing was performed at basal level and following in vitro stimulation with recombinant IL-2 and M. tuberculosis antigens. It was established that clinical course of infiltrative pulmonary tuberculosis, independently on drug sensitivity/resistance of the infectious pathogen, is accompanied by suppression of spontaneous lymphoproliferation. The levels of induced IL-2 production in drug-sensitive tuberculosis proved to be increased, whereas a reserve of IL-2-secreting reactivity of blood lymphocytes was lower than in drugresistant infection. Also, it was revealed that the level of lymphoproliferative response induced by IL-2, does not depend on clinical variant of tuberculosis, whereas stimulation of IL-2 production in blood lymphocytes is attained only in cases of drug-resistant tuberculosis variant.
format	article
author	R. R. Khasanova O. V. Voronkova O. I. Urazova V. V. Novitsky A. K. Strelis Yu. V. Stambula A. E. Kolosova V. A. Serebryakova I. O. Naslednikova O. V. Kolokolova T. E. Budkina N. P. Pirogova
author_facet	R. R. Khasanova O. V. Voronkova O. I. Urazova V. V. Novitsky A. K. Strelis Yu. V. Stambula A. E. Kolosova V. A. Serebryakova I. O. Naslednikova O. V. Kolokolova T. E. Budkina N. P. Pirogova
author_sort	R. R. Khasanova
title	REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS
title_short	REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS
title_full	REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS
title_fullStr	REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS
title_full_unstemmed	REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS
title_sort	reactivity of blood lymphocytes in pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/0f8520d5db3c4da18da6c2fc7d86cdae
work_keys_str_mv	AT rrkhasanova reactivityofbloodlymphocytesinpulmonarytuberculosis AT ovvoronkova reactivityofbloodlymphocytesinpulmonarytuberculosis AT oiurazova reactivityofbloodlymphocytesinpulmonarytuberculosis AT vvnovitsky reactivityofbloodlymphocytesinpulmonarytuberculosis AT akstrelis reactivityofbloodlymphocytesinpulmonarytuberculosis AT yuvstambula reactivityofbloodlymphocytesinpulmonarytuberculosis AT aekolosova reactivityofbloodlymphocytesinpulmonarytuberculosis AT vaserebryakova reactivityofbloodlymphocytesinpulmonarytuberculosis AT ionaslednikova reactivityofbloodlymphocytesinpulmonarytuberculosis AT ovkolokolova reactivityofbloodlymphocytesinpulmonarytuberculosis AT tebudkina reactivityofbloodlymphocytesinpulmonarytuberculosis AT nppirogova reactivityofbloodlymphocytesinpulmonarytuberculosis
_version_	1718422588411084800

REACTIVITY OF BLOOD LYMPHOCYTES IN PULMONARY TUBERCULOSIS

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