A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma

Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with P...

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Autores principales: Maolei Zhang, Kun Zhao, Xiaoping Xu, Yibing Yang, Sheng Yan, Ping Wei, Hui Liu, Jianbo Xu, Feizhe Xiao, Huangkai Zhou, Xuesong Yang, Nunu Huang, Jinglei Liu, Kejun He, Keping Xie, Gong Zhang, Suyun Huang, Nu Zhang
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/0f866c6231f8431bafdb3689de144299
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spelling oai:doaj.org-article:0f866c6231f8431bafdb3689de1442992021-12-02T17:32:17ZA peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma10.1038/s41467-018-06862-22041-1723https://doaj.org/article/0f866c6231f8431bafdb3689de1442992018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06862-2https://doaj.org/toc/2041-1723Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes.Maolei ZhangKun ZhaoXiaoping XuYibing YangSheng YanPing WeiHui LiuJianbo XuFeizhe XiaoHuangkai ZhouXuesong YangNunu HuangJinglei LiuKejun HeKeping XieGong ZhangSuyun HuangNu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Maolei Zhang
Kun Zhao
Xiaoping Xu
Yibing Yang
Sheng Yan
Ping Wei
Hui Liu
Jianbo Xu
Feizhe Xiao
Huangkai Zhou
Xuesong Yang
Nunu Huang
Jinglei Liu
Kejun He
Keping Xie
Gong Zhang
Suyun Huang
Nu Zhang
A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
description Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes.
format article
author Maolei Zhang
Kun Zhao
Xiaoping Xu
Yibing Yang
Sheng Yan
Ping Wei
Hui Liu
Jianbo Xu
Feizhe Xiao
Huangkai Zhou
Xuesong Yang
Nunu Huang
Jinglei Liu
Kejun He
Keping Xie
Gong Zhang
Suyun Huang
Nu Zhang
author_facet Maolei Zhang
Kun Zhao
Xiaoping Xu
Yibing Yang
Sheng Yan
Ping Wei
Hui Liu
Jianbo Xu
Feizhe Xiao
Huangkai Zhou
Xuesong Yang
Nunu Huang
Jinglei Liu
Kejun He
Keping Xie
Gong Zhang
Suyun Huang
Nu Zhang
author_sort Maolei Zhang
title A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
title_short A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
title_full A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
title_fullStr A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
title_full_unstemmed A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma
title_sort peptide encoded by circular form of linc-pint suppresses oncogenic transcriptional elongation in glioblastoma
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/0f866c6231f8431bafdb3689de144299
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