Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits

Background: We studied the influence on healing of a resorbable membrane covering the osteotomy site after maxillary sinus grafting, evaluated in different regions of the augmented area. Methods: Maxillary sinus augmentation was performed in 24 New Zealand rabbits. Osteotomy, 4 × 6 mm, were performe...

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Autores principales:	Alessandro Perini, Jose Viña-Almunia, Carmen Carda, José Javier Martín de Llano, Daniele Botticelli, Miguel Peñarrocha-Diago
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	animal study sinus floor elevation bone healing osteoconductivity histology morphometry Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/0f88fbb99e5341a092e80de9fa9b89dc
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spelling	oai:doaj.org-article:0f88fbb99e5341a092e80de9fa9b89dc2021-11-25T17:19:58ZInfluence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits10.3390/dj91101312304-6767https://doaj.org/article/0f88fbb99e5341a092e80de9fa9b89dc2021-11-01T00:00:00Zhttps://www.mdpi.com/2304-6767/9/11/131https://doaj.org/toc/2304-6767Background: We studied the influence on healing of a resorbable membrane covering the osteotomy site after maxillary sinus grafting, evaluated in different regions of the augmented area. Methods: Maxillary sinus augmentation was performed in 24 New Zealand rabbits. Osteotomy, 4 × 6 mm, were performed bilaterally. A collagenated cortico-cancellous porcine bone was used to fill the elevated region. A collagen membrane was randomly placed over the osteotomy site on one side (MG), and the other side was left uncovered (NMG). The animals were euthanized after 2, 4, and 8 weeks; and histomorphometric analysis was performed in eight different regions. Results: New bone percentages were similar in both groups. There were no statistically significant differences. In MG, the overall percentages were 15.6 ± 7.3%, 22.9 ± 6.1%, and 24.9 ± 12.0% after 2, 4, and 8 weeks, respectively. In NMG, the percentages were 11.2 ± 4.5%, 24.1 ± 5.7%, and 24.5 ± 15.7%, respectively. The proportions of new bone in the various regions after 8 weeks were 31 ± 8.9% and 29.9 ± 9.1% in the bone walls region, 25 ± 10.1% and 32.8 ± 9.1% in the submucosa region, 22.6 ± 21.6% and 10.9 ± 11.5 in the middle region, 17.3 ± 14% and 13.4 ± 9.8% in the close-to-window region, and 21.8 ± 11.6%, 19.1 ± 6.4% in the osteotomy region—for MG and NMG, respectively. Conclusions: In both groups the greatest amounts of bone formation occurred near to the pre-existing bone walls, followed by the sub-mucosa region. The smallest amounts were found in the close-to-window region, followed by the central region. The placement of a collagen membrane to cover the osteotomy site did not influence the amount of new bone formation after sinus grafting.Alessandro PeriniJose Viña-AlmuniaCarmen CardaJosé Javier Martín de LlanoDaniele BotticelliMiguel Peñarrocha-DiagoMDPI AGarticleanimal studysinus floor elevationbone healingosteoconductivityhistologymorphometryDentistryRK1-715ENDentistry Journal, Vol 9, Iss 131, p 131 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	animal study sinus floor elevation bone healing osteoconductivity histology morphometry Dentistry RK1-715
spellingShingle	animal study sinus floor elevation bone healing osteoconductivity histology morphometry Dentistry RK1-715 Alessandro Perini Jose Viña-Almunia Carmen Carda José Javier Martín de Llano Daniele Botticelli Miguel Peñarrocha-Diago Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits
description	Background: We studied the influence on healing of a resorbable membrane covering the osteotomy site after maxillary sinus grafting, evaluated in different regions of the augmented area. Methods: Maxillary sinus augmentation was performed in 24 New Zealand rabbits. Osteotomy, 4 × 6 mm, were performed bilaterally. A collagenated cortico-cancellous porcine bone was used to fill the elevated region. A collagen membrane was randomly placed over the osteotomy site on one side (MG), and the other side was left uncovered (NMG). The animals were euthanized after 2, 4, and 8 weeks; and histomorphometric analysis was performed in eight different regions. Results: New bone percentages were similar in both groups. There were no statistically significant differences. In MG, the overall percentages were 15.6 ± 7.3%, 22.9 ± 6.1%, and 24.9 ± 12.0% after 2, 4, and 8 weeks, respectively. In NMG, the percentages were 11.2 ± 4.5%, 24.1 ± 5.7%, and 24.5 ± 15.7%, respectively. The proportions of new bone in the various regions after 8 weeks were 31 ± 8.9% and 29.9 ± 9.1% in the bone walls region, 25 ± 10.1% and 32.8 ± 9.1% in the submucosa region, 22.6 ± 21.6% and 10.9 ± 11.5 in the middle region, 17.3 ± 14% and 13.4 ± 9.8% in the close-to-window region, and 21.8 ± 11.6%, 19.1 ± 6.4% in the osteotomy region—for MG and NMG, respectively. Conclusions: In both groups the greatest amounts of bone formation occurred near to the pre-existing bone walls, followed by the sub-mucosa region. The smallest amounts were found in the close-to-window region, followed by the central region. The placement of a collagen membrane to cover the osteotomy site did not influence the amount of new bone formation after sinus grafting.
format	article
author	Alessandro Perini Jose Viña-Almunia Carmen Carda José Javier Martín de Llano Daniele Botticelli Miguel Peñarrocha-Diago
author_facet	Alessandro Perini Jose Viña-Almunia Carmen Carda José Javier Martín de Llano Daniele Botticelli Miguel Peñarrocha-Diago
author_sort	Alessandro Perini
title	Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits
title_short	Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits
title_full	Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits
title_fullStr	Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits
title_full_unstemmed	Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits
title_sort	influence of the use of a collagen membrane placed on the bone window after sinus floor augmentation—an experimental study in rabbits
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0f88fbb99e5341a092e80de9fa9b89dc
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Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits

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