Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats

Abstract To investigate the effect of duodenal-jejunal bypass (DJB) surgery on postoperative blood glucose in type 2 diabetic rats, and further explore possible mechanisms for the effect of surgical treatment of type 2 diabetes. Forty rats with type 2 diabetes were randomly assigned to 4 groups (n =...

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Autores principales:	Siqi Xie, MingChang Wang, Bin Zhang, ShanGeng Weng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f89dfa7057040d8a7c77fb7d0dc1cd0
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spelling	oai:doaj.org-article:0f89dfa7057040d8a7c77fb7d0dc1cd02021-11-08T10:51:27ZHypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats10.1038/s41598-021-98714-12045-2322https://doaj.org/article/0f89dfa7057040d8a7c77fb7d0dc1cd02021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98714-1https://doaj.org/toc/2045-2322Abstract To investigate the effect of duodenal-jejunal bypass (DJB) surgery on postoperative blood glucose in type 2 diabetic rats, and further explore possible mechanisms for the effect of surgical treatment of type 2 diabetes. Forty rats with type 2 diabetes were randomly assigned to 4 groups (n = 10 rats per group), which subsequently underwent DJB, new biliopancreatic diversion (NBPD) or duodenal-jejunal exclusion (DJE) surgery or a sham operation (SHAM). Fasting glucose, 2-h postprandial glucose and blood lipids were measured, and the mRNA in liver and intestinal tissue for bile acid receptor (FXR), as well as the FXR protein expression in the liver tissues were determined. Postprandial blood glucose and fasting TG and FFA in the DJB and NBPD groups were significantly lower than those in the SHAM group and preoperative (p < 0.05) at 8 weeks postoperation. Liver FXR protein was expressed at significantly higher in the DJB and NBPD groups than in the other two (p < 0.05), and the intestinal FXR mRNA in the DJE group were highest. DJB up-regulates the expression of bile acid receptors in the liver and down-regulates those receptors in the intestinal tract via biliopancreatic diversion. This process reduces TG levels, and subsequently any lipotoxicity to islet cells to produce a hypoglycemic effect.Siqi XieMingChang WangBin ZhangShanGeng WengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Siqi Xie MingChang Wang Bin Zhang ShanGeng Weng Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats
description	Abstract To investigate the effect of duodenal-jejunal bypass (DJB) surgery on postoperative blood glucose in type 2 diabetic rats, and further explore possible mechanisms for the effect of surgical treatment of type 2 diabetes. Forty rats with type 2 diabetes were randomly assigned to 4 groups (n = 10 rats per group), which subsequently underwent DJB, new biliopancreatic diversion (NBPD) or duodenal-jejunal exclusion (DJE) surgery or a sham operation (SHAM). Fasting glucose, 2-h postprandial glucose and blood lipids were measured, and the mRNA in liver and intestinal tissue for bile acid receptor (FXR), as well as the FXR protein expression in the liver tissues were determined. Postprandial blood glucose and fasting TG and FFA in the DJB and NBPD groups were significantly lower than those in the SHAM group and preoperative (p < 0.05) at 8 weeks postoperation. Liver FXR protein was expressed at significantly higher in the DJB and NBPD groups than in the other two (p < 0.05), and the intestinal FXR mRNA in the DJE group were highest. DJB up-regulates the expression of bile acid receptors in the liver and down-regulates those receptors in the intestinal tract via biliopancreatic diversion. This process reduces TG levels, and subsequently any lipotoxicity to islet cells to produce a hypoglycemic effect.
format	article
author	Siqi Xie MingChang Wang Bin Zhang ShanGeng Weng
author_facet	Siqi Xie MingChang Wang Bin Zhang ShanGeng Weng
author_sort	Siqi Xie
title	Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats
title_short	Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats
title_full	Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats
title_fullStr	Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats
title_full_unstemmed	Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats
title_sort	hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0f89dfa7057040d8a7c77fb7d0dc1cd0
work_keys_str_mv	AT siqixie hypoglycemicmechanismofintestinalbypasssurgeryintype2diabeticrats AT mingchangwang hypoglycemicmechanismofintestinalbypasssurgeryintype2diabeticrats AT binzhang hypoglycemicmechanismofintestinalbypasssurgeryintype2diabeticrats AT shangengweng hypoglycemicmechanismofintestinalbypasssurgeryintype2diabeticrats
_version_	1718442496041680896

Hypoglycemic mechanism of intestinal bypass surgery in type 2 diabetic rats

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