Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning

This study investigates the ability of blood neutrophil-to-lymphocyte ratio (NLR) to predict acute organophosphorus pesticide poisoning (AOPP). Clinical data of 385 patients with AOPP were obtained within 24 h of admission, and NLR values were calculated based on neutrophil and lymphocyte counts. Th...

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Autores principales:	Mu Yuhang, Hu Boqi, Gao Nan, Pang Li
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	aopp nlr public health risk factor prognosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0f8a5f45cff24d4480ad97624e62e623
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spelling	oai:doaj.org-article:0f8a5f45cff24d4480ad97624e62e6232021-12-05T14:10:41ZPrognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning2391-541210.1515/biol-2021-0069https://doaj.org/article/0f8a5f45cff24d4480ad97624e62e6232021-07-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0069https://doaj.org/toc/2391-5412This study investigates the ability of blood neutrophil-to-lymphocyte ratio (NLR) to predict acute organophosphorus pesticide poisoning (AOPP). Clinical data of 385 patients with AOPP were obtained within 24 h of admission, and NLR values were calculated based on neutrophil and lymphocyte counts. The patients were divided into two groups – good and poor – based on prognosis. Poor prognosis included in-hospital death and severe poisoning. The factors affecting prognosis were analyzed by logistic regression analysis, and the prognostic value of NLR was evaluated using the area under the receiver operating characteristic curve (AUC). Univariate logistic regression analysis showed that NLR levels, serum cholinesterase, and creatinine levels were good predictors of AOPP. Multivariate logistic regression analysis showed that high NLR was an independent risk factor for severe poisoning (adjusted odds ratio [AOR], 1.13; 95% CI, 1.10–1.17; p < 0.05) and in-hospital mortality (AOR, 1.07; 95% CI, 1.03–1.11; p < 0.05). NLR values >13 and >17 had a moderate ability to predict severe poisoning and in-hospital mortality, respectively (AUC of 0.782 [95% CI, 0.74–0.824] and 0.714 [95% CI, 0.626–0.803], respectively). Our results show that high NLR at admission is an independent indicator of poor prognosis in AOPP and can be used to optimize treatment and manage patients.Mu YuhangHu BoqiGao NanPang LiDe Gruyterarticleaoppnlrpublic healthrisk factorprognosisBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 703-710 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aopp nlr public health risk factor prognosis Biology (General) QH301-705.5
spellingShingle	aopp nlr public health risk factor prognosis Biology (General) QH301-705.5 Mu Yuhang Hu Boqi Gao Nan Pang Li Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
description	This study investigates the ability of blood neutrophil-to-lymphocyte ratio (NLR) to predict acute organophosphorus pesticide poisoning (AOPP). Clinical data of 385 patients with AOPP were obtained within 24 h of admission, and NLR values were calculated based on neutrophil and lymphocyte counts. The patients were divided into two groups – good and poor – based on prognosis. Poor prognosis included in-hospital death and severe poisoning. The factors affecting prognosis were analyzed by logistic regression analysis, and the prognostic value of NLR was evaluated using the area under the receiver operating characteristic curve (AUC). Univariate logistic regression analysis showed that NLR levels, serum cholinesterase, and creatinine levels were good predictors of AOPP. Multivariate logistic regression analysis showed that high NLR was an independent risk factor for severe poisoning (adjusted odds ratio [AOR], 1.13; 95% CI, 1.10–1.17; p < 0.05) and in-hospital mortality (AOR, 1.07; 95% CI, 1.03–1.11; p < 0.05). NLR values >13 and >17 had a moderate ability to predict severe poisoning and in-hospital mortality, respectively (AUC of 0.782 [95% CI, 0.74–0.824] and 0.714 [95% CI, 0.626–0.803], respectively). Our results show that high NLR at admission is an independent indicator of poor prognosis in AOPP and can be used to optimize treatment and manage patients.
format	article
author	Mu Yuhang Hu Boqi Gao Nan Pang Li
author_facet	Mu Yuhang Hu Boqi Gao Nan Pang Li
author_sort	Mu Yuhang
title	Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
title_short	Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
title_full	Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
title_fullStr	Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
title_full_unstemmed	Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
title_sort	prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/0f8a5f45cff24d4480ad97624e62e623
work_keys_str_mv	AT muyuhang prognosticvalueoftheneutrophiltolymphocyteratioinacuteorganophosphoruspesticidepoisoning AT huboqi prognosticvalueoftheneutrophiltolymphocyteratioinacuteorganophosphoruspesticidepoisoning AT gaonan prognosticvalueoftheneutrophiltolymphocyteratioinacuteorganophosphoruspesticidepoisoning AT pangli prognosticvalueoftheneutrophiltolymphocyteratioinacuteorganophosphoruspesticidepoisoning
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Prognostic value of the neutrophil-to-lymphocyte ratio in acute organophosphorus pesticide poisoning

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