A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration

A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Here, the authors show that mutations in connexin 32 can cause failures in membrane integration which is detected by the ER chaperone machinery.

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Autores principales:	João P. L. Coelho, Matthias Stahl, Nicolas Bloemeke, Kevin Meighen-Berger, Carlos Piedrafita Alvira, Zai-Rong Zhang, Stephan A. Sieber, Matthias J. Feige
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0f8fc492c9d64d8195722eb23af030af
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spelling	oai:doaj.org-article:0f8fc492c9d64d8195722eb23af030af2021-12-02T16:57:11ZA network of chaperones prevents and detects failures in membrane protein lipid bilayer integration10.1038/s41467-019-08632-02041-1723https://doaj.org/article/0f8fc492c9d64d8195722eb23af030af2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08632-0https://doaj.org/toc/2041-1723A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Here, the authors show that mutations in connexin 32 can cause failures in membrane integration which is detected by the ER chaperone machinery.João P. L. CoelhoMatthias StahlNicolas BloemekeKevin Meighen-BergerCarlos Piedrafita AlviraZai-Rong ZhangStephan A. SieberMatthias J. FeigeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q João P. L. Coelho Matthias Stahl Nicolas Bloemeke Kevin Meighen-Berger Carlos Piedrafita Alvira Zai-Rong Zhang Stephan A. Sieber Matthias J. Feige A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
description	A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Here, the authors show that mutations in connexin 32 can cause failures in membrane integration which is detected by the ER chaperone machinery.
format	article
author	João P. L. Coelho Matthias Stahl Nicolas Bloemeke Kevin Meighen-Berger Carlos Piedrafita Alvira Zai-Rong Zhang Stephan A. Sieber Matthias J. Feige
author_facet	João P. L. Coelho Matthias Stahl Nicolas Bloemeke Kevin Meighen-Berger Carlos Piedrafita Alvira Zai-Rong Zhang Stephan A. Sieber Matthias J. Feige
author_sort	João P. L. Coelho
title	A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
title_short	A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
title_full	A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
title_fullStr	A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
title_full_unstemmed	A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
title_sort	network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/0f8fc492c9d64d8195722eb23af030af
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A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration

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