Exploration of a novel virtual environment improves memory consolidation in ADHD

Abstract Experimental evidence in rodents and humans suggests that long-term memory consolidation can be enhanced by the exploration of a novel environment presented during a vulnerable early phase of consolidation. This memory enhancing effect (behavioral tagging) is caused by dopaminergic and nora...

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Autores principales:	Valentin Baumann, Thomas Birnbaum, Carolin Breitling-Ziegler, Jana Tegelbeckers, Johannes Dambacher, Elke Edelmann, Jorge R. Bergado-Acosta, Hans-Henning Flechtner, Kerstin Krauel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f9075a712d24e94b321fca21bb34c49
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spelling	oai:doaj.org-article:0f9075a712d24e94b321fca21bb34c492021-12-02T16:18:02ZExploration of a novel virtual environment improves memory consolidation in ADHD10.1038/s41598-020-78222-42045-2322https://doaj.org/article/0f9075a712d24e94b321fca21bb34c492020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78222-4https://doaj.org/toc/2045-2322Abstract Experimental evidence in rodents and humans suggests that long-term memory consolidation can be enhanced by the exploration of a novel environment presented during a vulnerable early phase of consolidation. This memory enhancing effect (behavioral tagging) is caused by dopaminergic and noradrenergic neuromodulation of hippocampal plasticity processes. In translation from animal to human research, we investigated whether behavioral tagging with novelty can be used to tackle memory problems observed in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). 34 patients with ADHD and 34 typically developing participants (age 9–15 years) explored either a previously familiarized or a novel virtual environment 45 min after they had learned a list of 20 words. Participants took a free recall test both immediately after learning the word list and after 24 h. Patients who explored a familiar environment showed significantly impaired memory consolidation compared to typically developing peers. Exploration of a novel environment led to significantly better memory consolidation in children and adolescents with ADHD. However, we did not observe a beneficial effect of novel environment exploration in typically developing participants. Our data rather suggested that increased exploration of a novel environment as well as higher feelings of virtual immersion compromised memory performance in typically developing children and adolescents, which was not the case for patients with ADHD. We propose that behavioral tagging with novel virtual environments is a promising candidate to overcome ADHD related memory problems. Moreover, the discrepancy between children and adolescents with and without ADHD suggests that behavioral tagging might only be able to improve memory consolidation for weakly encoded information.Valentin BaumannThomas BirnbaumCarolin Breitling-ZieglerJana TegelbeckersJohannes DambacherElke EdelmannJorge R. Bergado-AcostaHans-Henning FlechtnerKerstin KrauelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Valentin Baumann Thomas Birnbaum Carolin Breitling-Ziegler Jana Tegelbeckers Johannes Dambacher Elke Edelmann Jorge R. Bergado-Acosta Hans-Henning Flechtner Kerstin Krauel Exploration of a novel virtual environment improves memory consolidation in ADHD
description	Abstract Experimental evidence in rodents and humans suggests that long-term memory consolidation can be enhanced by the exploration of a novel environment presented during a vulnerable early phase of consolidation. This memory enhancing effect (behavioral tagging) is caused by dopaminergic and noradrenergic neuromodulation of hippocampal plasticity processes. In translation from animal to human research, we investigated whether behavioral tagging with novelty can be used to tackle memory problems observed in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). 34 patients with ADHD and 34 typically developing participants (age 9–15 years) explored either a previously familiarized or a novel virtual environment 45 min after they had learned a list of 20 words. Participants took a free recall test both immediately after learning the word list and after 24 h. Patients who explored a familiar environment showed significantly impaired memory consolidation compared to typically developing peers. Exploration of a novel environment led to significantly better memory consolidation in children and adolescents with ADHD. However, we did not observe a beneficial effect of novel environment exploration in typically developing participants. Our data rather suggested that increased exploration of a novel environment as well as higher feelings of virtual immersion compromised memory performance in typically developing children and adolescents, which was not the case for patients with ADHD. We propose that behavioral tagging with novel virtual environments is a promising candidate to overcome ADHD related memory problems. Moreover, the discrepancy between children and adolescents with and without ADHD suggests that behavioral tagging might only be able to improve memory consolidation for weakly encoded information.
format	article
author	Valentin Baumann Thomas Birnbaum Carolin Breitling-Ziegler Jana Tegelbeckers Johannes Dambacher Elke Edelmann Jorge R. Bergado-Acosta Hans-Henning Flechtner Kerstin Krauel
author_facet	Valentin Baumann Thomas Birnbaum Carolin Breitling-Ziegler Jana Tegelbeckers Johannes Dambacher Elke Edelmann Jorge R. Bergado-Acosta Hans-Henning Flechtner Kerstin Krauel
author_sort	Valentin Baumann
title	Exploration of a novel virtual environment improves memory consolidation in ADHD
title_short	Exploration of a novel virtual environment improves memory consolidation in ADHD
title_full	Exploration of a novel virtual environment improves memory consolidation in ADHD
title_fullStr	Exploration of a novel virtual environment improves memory consolidation in ADHD
title_full_unstemmed	Exploration of a novel virtual environment improves memory consolidation in ADHD
title_sort	exploration of a novel virtual environment improves memory consolidation in adhd
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/0f9075a712d24e94b321fca21bb34c49
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Exploration of a novel virtual environment improves memory consolidation in ADHD

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