Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se

Boshra Al-Absi, Molham AL-Habori, Riyadh Saif-Ali Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, YemenCorrespondence: Molham AL-Habori Email malhabori@hotmail.comPurpose: Changes in plasma adipocytokines and inflammatory marke...

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Autores principales:	Al-Absi B, AL-Habori M, Saif-Ali R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	lipocalin-2 adiponectin interleukin-1β obesity type 2 dm Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/0f91ecce98914644b29fdd08acfd8df6
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spelling	oai:doaj.org-article:0f91ecce98914644b29fdd08acfd8df62021-12-02T18:43:43ZPlasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se1178-7007https://doaj.org/article/0f91ecce98914644b29fdd08acfd8df62021-11-01T00:00:00Zhttps://www.dovepress.com/plasma-lipocalin-2-and-adiponectin-are-affected-by-obesity-rather-than-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Boshra Al-Absi, Molham AL-Habori, Riyadh Saif-Ali Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, YemenCorrespondence: Molham AL-Habori Email malhabori@hotmail.comPurpose: Changes in plasma adipocytokines and inflammatory markers in type 2 DM remain controversial as to whether they are due to obesity or directly associated with the diabetic state. Our objective was to study the effect of obesity and diabetes on plasma lipocalin-2 (LCN2), adiponectin, and interleukin-1β (IL-1β) by comparing their levels in non-diabetic obese subjects and non-obese type 2 DM patients, as well as determining the association of these adipocytokines with metabolic syndrome factors and diabetic parameters.Patients and Methods: In this study, 85 Yemeni male volunteers aged 30– 60 years old were enrolled, 25 of whom were healthy subjects with BMI < 25 kg/m2 served as control; 30 non-diabetic obese subjects (BMI ≥ 30 kg/m2 and FBG < 6.1 mmol/l); and 30 non-obese type 2 DM patients (BMI < 25 kg/m2 and FBG > 7 mmol/l).Results: Lipocalin-2 and adiponectin were significantly (p = 0.043 and p = 0.034) lower in non-diabetic obese subjects by 16.2% and 29.7% with respect to control group, with no effect in the non-obese type 2 DM patients. Moreover, LCN2 was significantly (p = 0.04) lower in the non-diabetic obese subjects by 15.8% as compared with the non-obese type 2 DM patients, with no significant difference in adiponectin levels. In contrast, serum IL-1β was significantly (p = 0.001 and p = 0.003) higher in both non-diabetic obese subjects and the non-obese type 2 DM patients by 76.5% and 67.7% as compared to control group. The significant decrease in both LCN2 and adiponectin and the significant increase in IL-1β in the non-diabetic obese subjects disappeared upon adjustment for waist circumference (WC). In contrast, the significant increase in IL-1β in the non-obese Type 2 DM patients was not affected upon adjustment for WC.Conclusion: Plasma LCN2 and adiponectin were not affected by diabetes per se, suggesting that the observed changes in LCN2 and adiponectin in type 2 DM may be due to obesity rather than the diabetic state, whereas IL-1β levels were affected by both obesity and diabetes.Keywords: lipocalin-2, adiponectin, interleukin-1β, obesity, type 2 DMAl-Absi BAL-Habori MSaif-Ali RDove Medical Pressarticlelipocalin-2adiponectininterleukin-1βobesitytype 2 dmSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4547-4556 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lipocalin-2 adiponectin interleukin-1β obesity type 2 dm Specialties of internal medicine RC581-951
spellingShingle	lipocalin-2 adiponectin interleukin-1β obesity type 2 dm Specialties of internal medicine RC581-951 Al-Absi B AL-Habori M Saif-Ali R Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se
description	Boshra Al-Absi, Molham AL-Habori, Riyadh Saif-Ali Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, University of Sana`a, Sana`a, YemenCorrespondence: Molham AL-Habori Email malhabori@hotmail.comPurpose: Changes in plasma adipocytokines and inflammatory markers in type 2 DM remain controversial as to whether they are due to obesity or directly associated with the diabetic state. Our objective was to study the effect of obesity and diabetes on plasma lipocalin-2 (LCN2), adiponectin, and interleukin-1β (IL-1β) by comparing their levels in non-diabetic obese subjects and non-obese type 2 DM patients, as well as determining the association of these adipocytokines with metabolic syndrome factors and diabetic parameters.Patients and Methods: In this study, 85 Yemeni male volunteers aged 30– 60 years old were enrolled, 25 of whom were healthy subjects with BMI < 25 kg/m2 served as control; 30 non-diabetic obese subjects (BMI ≥ 30 kg/m2 and FBG < 6.1 mmol/l); and 30 non-obese type 2 DM patients (BMI < 25 kg/m2 and FBG > 7 mmol/l).Results: Lipocalin-2 and adiponectin were significantly (p = 0.043 and p = 0.034) lower in non-diabetic obese subjects by 16.2% and 29.7% with respect to control group, with no effect in the non-obese type 2 DM patients. Moreover, LCN2 was significantly (p = 0.04) lower in the non-diabetic obese subjects by 15.8% as compared with the non-obese type 2 DM patients, with no significant difference in adiponectin levels. In contrast, serum IL-1β was significantly (p = 0.001 and p = 0.003) higher in both non-diabetic obese subjects and the non-obese type 2 DM patients by 76.5% and 67.7% as compared to control group. The significant decrease in both LCN2 and adiponectin and the significant increase in IL-1β in the non-diabetic obese subjects disappeared upon adjustment for waist circumference (WC). In contrast, the significant increase in IL-1β in the non-obese Type 2 DM patients was not affected upon adjustment for WC.Conclusion: Plasma LCN2 and adiponectin were not affected by diabetes per se, suggesting that the observed changes in LCN2 and adiponectin in type 2 DM may be due to obesity rather than the diabetic state, whereas IL-1β levels were affected by both obesity and diabetes.Keywords: lipocalin-2, adiponectin, interleukin-1β, obesity, type 2 DM
format	article
author	Al-Absi B AL-Habori M Saif-Ali R
author_facet	Al-Absi B AL-Habori M Saif-Ali R
author_sort	Al-Absi B
title	Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se
title_short	Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se
title_full	Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se
title_fullStr	Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se
title_full_unstemmed	Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se
title_sort	plasma lipocalin-2 and adiponectin are affected by obesity rather than type 2 diabetes mellitus per se
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/0f91ecce98914644b29fdd08acfd8df6
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Plasma Lipocalin-2 and Adiponectin are Affected by Obesity Rather Than Type 2 Diabetes Mellitus per se

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