ESR1 amplification in breast cancer by optimized RNase FISH: frequent but low-level and heterogeneous.

Prevalence of ESR1 amplification in breast cancer is highly disputed and discrepancies have been related to different technical protocols and different scoring approaches. In addition, pre-mRNA artifacts have been proposed to influence outcome of ESR1 FISH analysis. We analyzed ESR1 gene copy number...

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Bibliographic Details
Main Authors: Cathy B Moelans, Frederik Holst, Olaf Hellwinkel, Ronald Simon, Paul J van Diest
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
R
Q
Online Access:https://doaj.org/article/0f96661f173f4429996bf67558021dab
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