Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.

<h4>Background</h4>Iron oxide nanoparticles (IONs) are a promising nanoplatform for contrast-enhanced MRI. Recently, magnetic particle imaging (MPI) was introduced as a new imaging modality, which is able to directly visualize magnetic particles and could serve as a more sensitive and qu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lucas W E Starmans, Dirk Burdinski, Nicole P M Haex, Rik P M Moonen, Gustav J Strijkers, Klaas Nicolay, Holger Grüll
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0f9a3fdbd92141efbea255726bcf3fc6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0f9a3fdbd92141efbea255726bcf3fc6
record_format	dspace
spelling	oai:doaj.org-article:0f9a3fdbd92141efbea255726bcf3fc62021-11-18T07:56:40ZIron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.1932-620310.1371/journal.pone.0057335https://doaj.org/article/0f9a3fdbd92141efbea255726bcf3fc62013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23437371/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Iron oxide nanoparticles (IONs) are a promising nanoplatform for contrast-enhanced MRI. Recently, magnetic particle imaging (MPI) was introduced as a new imaging modality, which is able to directly visualize magnetic particles and could serve as a more sensitive and quantitative alternative to MRI. However, MPI requires magnetic particles with specific magnetic properties for optimal use. Current commercially available iron oxide formulations perform suboptimal in MPI, which is triggering research into optimized synthesis strategies. Most synthesis procedures aim at size control of iron oxide nanoparticles rather than control over the magnetic properties. In this study, we report on the synthesis, characterization and application of a novel ION platform for sensitive MPI and MRI.<h4>Methods and results</h4>IONs were synthesized using a thermal-decomposition method and subsequently phase-transferred by encapsulation into lipidic micelles (ION-Micelles). Next, the material and magnetic properties of the ION-Micelles were analyzed. Most notably, vibrating sample magnetometry measurements showed that the effective magnetic core size of the IONs is 16 nm. In addition, magnetic particle spectrometry (MPS) measurements were performed. MPS is essentially zero-dimensional MPI and therefore allows to probe the potential of iron oxide formulations for MPI. ION-Micelles induced up to 200 times higher signal in MPS measurements than commercially available iron oxide formulations (Endorem, Resovist and Sinerem) and thus likely allow for significantly more sensitive MPI. In addition, the potential of the ION-Micelle platform for molecular MPI and MRI was showcased by MPS and MRI measurements of fibrin-binding peptide functionalized ION-Micelles (FibPep-ION-Micelles) bound to blood clots.<h4>Conclusions</h4>The presented data underlines the potential of the ION-Micelle nanoplatform for sensitive (molecular) MPI and warrants further investigation of the FibPep-ION-Micelle platform for in vivo, non-invasive imaging of fibrin in preclinical disease models of thrombus-related pathologies and atherosclerosis.Lucas W E StarmansDirk BurdinskiNicole P M HaexRik P M MoonenGustav J StrijkersKlaas NicolayHolger GrüllPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57335 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lucas W E Starmans Dirk Burdinski Nicole P M Haex Rik P M Moonen Gustav J Strijkers Klaas Nicolay Holger Grüll Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.
description	<h4>Background</h4>Iron oxide nanoparticles (IONs) are a promising nanoplatform for contrast-enhanced MRI. Recently, magnetic particle imaging (MPI) was introduced as a new imaging modality, which is able to directly visualize magnetic particles and could serve as a more sensitive and quantitative alternative to MRI. However, MPI requires magnetic particles with specific magnetic properties for optimal use. Current commercially available iron oxide formulations perform suboptimal in MPI, which is triggering research into optimized synthesis strategies. Most synthesis procedures aim at size control of iron oxide nanoparticles rather than control over the magnetic properties. In this study, we report on the synthesis, characterization and application of a novel ION platform for sensitive MPI and MRI.<h4>Methods and results</h4>IONs were synthesized using a thermal-decomposition method and subsequently phase-transferred by encapsulation into lipidic micelles (ION-Micelles). Next, the material and magnetic properties of the ION-Micelles were analyzed. Most notably, vibrating sample magnetometry measurements showed that the effective magnetic core size of the IONs is 16 nm. In addition, magnetic particle spectrometry (MPS) measurements were performed. MPS is essentially zero-dimensional MPI and therefore allows to probe the potential of iron oxide formulations for MPI. ION-Micelles induced up to 200 times higher signal in MPS measurements than commercially available iron oxide formulations (Endorem, Resovist and Sinerem) and thus likely allow for significantly more sensitive MPI. In addition, the potential of the ION-Micelle platform for molecular MPI and MRI was showcased by MPS and MRI measurements of fibrin-binding peptide functionalized ION-Micelles (FibPep-ION-Micelles) bound to blood clots.<h4>Conclusions</h4>The presented data underlines the potential of the ION-Micelle nanoplatform for sensitive (molecular) MPI and warrants further investigation of the FibPep-ION-Micelle platform for in vivo, non-invasive imaging of fibrin in preclinical disease models of thrombus-related pathologies and atherosclerosis.
format	article
author	Lucas W E Starmans Dirk Burdinski Nicole P M Haex Rik P M Moonen Gustav J Strijkers Klaas Nicolay Holger Grüll
author_facet	Lucas W E Starmans Dirk Burdinski Nicole P M Haex Rik P M Moonen Gustav J Strijkers Klaas Nicolay Holger Grüll
author_sort	Lucas W E Starmans
title	Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.
title_short	Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.
title_full	Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.
title_fullStr	Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.
title_full_unstemmed	Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.
title_sort	iron oxide nanoparticle-micelles (ion-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/0f9a3fdbd92141efbea255726bcf3fc6
work_keys_str_mv	AT lucaswestarmans ironoxidenanoparticlemicellesionmicellesforsensitivemolecularmagneticparticleimagingandmagneticresonanceimaging AT dirkburdinski ironoxidenanoparticlemicellesionmicellesforsensitivemolecularmagneticparticleimagingandmagneticresonanceimaging AT nicolepmhaex ironoxidenanoparticlemicellesionmicellesforsensitivemolecularmagneticparticleimagingandmagneticresonanceimaging AT rikpmmoonen ironoxidenanoparticlemicellesionmicellesforsensitivemolecularmagneticparticleimagingandmagneticresonanceimaging AT gustavjstrijkers ironoxidenanoparticlemicellesionmicellesforsensitivemolecularmagneticparticleimagingandmagneticresonanceimaging AT klaasnicolay ironoxidenanoparticlemicellesionmicellesforsensitivemolecularmagneticparticleimagingandmagneticresonanceimaging AT holgergrull ironoxidenanoparticlemicellesionmicellesforsensitivemolecularmagneticparticleimagingandmagneticresonanceimaging
_version_	1718422711114399744

Iron oxide nanoparticle-micelles (ION-micelles) for sensitive (molecular) magnetic particle imaging and magnetic resonance imaging.

Ejemplares similares