Age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers

Background: Long-term, heavy alcohol consumption has been associated with impairments in control over alcohol use, but whether this extends to other areas of cognitive and behavioral control such as response inhibition remains unclear. Understanding individual differences in the neural correlates of...

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Autores principales:	Megan Swartz, Finnigan Burton, Kishore Vakamudi, Kareem Al-Khalil, Katie Witkiewitz, Eric D. Claus
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Response inhibition Alcohol use disorders Accelerated aging Error monitoring Sex differences Neuroimaging Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/0f9de276df8d4b6283954390e19c25f4
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spelling	oai:doaj.org-article:0f9de276df8d4b6283954390e19c25f42021-11-14T04:32:40ZAge dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers2213-158210.1016/j.nicl.2021.102875https://doaj.org/article/0f9de276df8d4b6283954390e19c25f42021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003193https://doaj.org/toc/2213-1582Background: Long-term, heavy alcohol consumption has been associated with impairments in control over alcohol use, but whether this extends to other areas of cognitive and behavioral control such as response inhibition remains unclear. Understanding individual differences in the neural correlates of response inhibition will provide further insight into the neurobiology of heavy drinking. The current study investigated response inhibition in a large sample of moderate to heavy drinkers Methods: One hundred fifty-three individuals completed a stop signal task while undergoing functional magnetic resonance imaging. Multiple regression analyses focused on blood oxygen level-dependent (BOLD) response contrasts of correct inhibition and failed inhibition as dependent variables and included age, sex, and hazardous drinking (as measured by the Alcohol Use Disorders Identification Test (AUDIT)), and their interactions, as independent variables Results: Age was negatively associated with BOLD response in lateral inferior and middle frontal gyri, anterior cingulate cortex, and inferior parietal lobe for both successful inhibition and failed inhibition contrasts. In addition, there was a significant age × AUDIT interaction in the successful inhibition contrast in the left middle frontal gyrus, with significant negative correlations between AUDIT and BOLD response in older participants, and a significant positive correlation between AUDIT and BOLD response in younger participants Conclusions: Age appears to be a particularly important factor in predicting BOLD response and may be a critical variable to include in future studies of heavy drinking and alcohol use disorder, particularly those that assess cognitive function. Finally, the age × AUDIT interaction observed in the current study may represent evidence for accelerated aging effects of alcohol on cognitive function.Megan SwartzFinnigan BurtonKishore VakamudiKareem Al-KhalilKatie WitkiewitzEric D. ClausElsevierarticleResponse inhibitionAlcohol use disordersAccelerated agingError monitoringSex differencesNeuroimagingComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102875- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Response inhibition Alcohol use disorders Accelerated aging Error monitoring Sex differences Neuroimaging Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Response inhibition Alcohol use disorders Accelerated aging Error monitoring Sex differences Neuroimaging Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Megan Swartz Finnigan Burton Kishore Vakamudi Kareem Al-Khalil Katie Witkiewitz Eric D. Claus Age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers
description	Background: Long-term, heavy alcohol consumption has been associated with impairments in control over alcohol use, but whether this extends to other areas of cognitive and behavioral control such as response inhibition remains unclear. Understanding individual differences in the neural correlates of response inhibition will provide further insight into the neurobiology of heavy drinking. The current study investigated response inhibition in a large sample of moderate to heavy drinkers Methods: One hundred fifty-three individuals completed a stop signal task while undergoing functional magnetic resonance imaging. Multiple regression analyses focused on blood oxygen level-dependent (BOLD) response contrasts of correct inhibition and failed inhibition as dependent variables and included age, sex, and hazardous drinking (as measured by the Alcohol Use Disorders Identification Test (AUDIT)), and their interactions, as independent variables Results: Age was negatively associated with BOLD response in lateral inferior and middle frontal gyri, anterior cingulate cortex, and inferior parietal lobe for both successful inhibition and failed inhibition contrasts. In addition, there was a significant age × AUDIT interaction in the successful inhibition contrast in the left middle frontal gyrus, with significant negative correlations between AUDIT and BOLD response in older participants, and a significant positive correlation between AUDIT and BOLD response in younger participants Conclusions: Age appears to be a particularly important factor in predicting BOLD response and may be a critical variable to include in future studies of heavy drinking and alcohol use disorder, particularly those that assess cognitive function. Finally, the age × AUDIT interaction observed in the current study may represent evidence for accelerated aging effects of alcohol on cognitive function.
format	article
author	Megan Swartz Finnigan Burton Kishore Vakamudi Kareem Al-Khalil Katie Witkiewitz Eric D. Claus
author_facet	Megan Swartz Finnigan Burton Kishore Vakamudi Kareem Al-Khalil Katie Witkiewitz Eric D. Claus
author_sort	Megan Swartz
title	Age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers
title_short	Age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers
title_full	Age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers
title_fullStr	Age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers
title_full_unstemmed	Age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers
title_sort	age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/0f9de276df8d4b6283954390e19c25f4
work_keys_str_mv	AT meganswartz agedependentneuralcorrelatesofinhibitionandcontrolmechanismsinmoderatetoheavydrinkers AT finniganburton agedependentneuralcorrelatesofinhibitionandcontrolmechanismsinmoderatetoheavydrinkers AT kishorevakamudi agedependentneuralcorrelatesofinhibitionandcontrolmechanismsinmoderatetoheavydrinkers AT kareemalkhalil agedependentneuralcorrelatesofinhibitionandcontrolmechanismsinmoderatetoheavydrinkers AT katiewitkiewitz agedependentneuralcorrelatesofinhibitionandcontrolmechanismsinmoderatetoheavydrinkers AT ericdclaus agedependentneuralcorrelatesofinhibitionandcontrolmechanismsinmoderatetoheavydrinkers
_version_	1718429940005732352

Age dependent neural correlates of inhibition and control mechanisms in moderate to heavy drinkers

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