Blockade of miR-140-3p prevents functional deterioration in afterload-enhanced engineered heart tissue

Abstract Afterload enhancement (AE) of rat engineered heart tissue (EHT) in vitro leads to a multitude of changes that in vivo are referred to as pathological cardiac hypertrophy: e.g., cardiomyocyte hypertrophy, contractile dysfunction, reactivation of fetal genes and fibrotic changes. Moreover AE...

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Autores principales: Tessa R. Werner, Ann-Cathrin Kunze, Justus Stenzig, Thomas Eschenhagen, Marc N. Hirt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/0fa1711dc2dc4da28a62e632b28a965e
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