Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms

Resistance-nodulation-cell division (RND)-type tripartite efflux pumps confer multidrug resistance to Gram-negative bacteria. Here, structural and functional analyses of AdeB from Acinetobacter baumannii and AcrB from Escherichia coli provide insight into their different drug-binding and conformatio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alina Ornik-Cha, Julia Wilhelm, Jessica Kobylka, Hanno Sjuts, Attilio V. Vargiu, Giuliano Malloci, Julian Reitz, Anja Seybert, Achilleas S. Frangakis, Klaas M. Pos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/0fa39d64c8884cc2b68766a6f47a6795
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0fa39d64c8884cc2b68766a6f47a6795
record_format	dspace
spelling	oai:doaj.org-article:0fa39d64c8884cc2b68766a6f47a67952021-11-28T12:32:06ZStructural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms10.1038/s41467-021-27146-22041-1723https://doaj.org/article/0fa39d64c8884cc2b68766a6f47a67952021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27146-2https://doaj.org/toc/2041-1723Resistance-nodulation-cell division (RND)-type tripartite efflux pumps confer multidrug resistance to Gram-negative bacteria. Here, structural and functional analyses of AdeB from Acinetobacter baumannii and AcrB from Escherichia coli provide insight into their different drug-binding and conformational drug transport states.Alina Ornik-ChaJulia WilhelmJessica KobylkaHanno SjutsAttilio V. VargiuGiuliano MallociJulian ReitzAnja SeybertAchilleas S. FrangakisKlaas M. PosNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alina Ornik-Cha Julia Wilhelm Jessica Kobylka Hanno Sjuts Attilio V. Vargiu Giuliano Malloci Julian Reitz Anja Seybert Achilleas S. Frangakis Klaas M. Pos Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
description	Resistance-nodulation-cell division (RND)-type tripartite efflux pumps confer multidrug resistance to Gram-negative bacteria. Here, structural and functional analyses of AdeB from Acinetobacter baumannii and AcrB from Escherichia coli provide insight into their different drug-binding and conformational drug transport states.
format	article
author	Alina Ornik-Cha Julia Wilhelm Jessica Kobylka Hanno Sjuts Attilio V. Vargiu Giuliano Malloci Julian Reitz Anja Seybert Achilleas S. Frangakis Klaas M. Pos
author_facet	Alina Ornik-Cha Julia Wilhelm Jessica Kobylka Hanno Sjuts Attilio V. Vargiu Giuliano Malloci Julian Reitz Anja Seybert Achilleas S. Frangakis Klaas M. Pos
author_sort	Alina Ornik-Cha
title	Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
title_short	Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
title_full	Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
title_fullStr	Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
title_full_unstemmed	Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms
title_sort	structural and functional analysis of the promiscuous acrb and adeb efflux pumps suggests different drug binding mechanisms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0fa39d64c8884cc2b68766a6f47a6795
work_keys_str_mv	AT alinaornikcha structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT juliawilhelm structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT jessicakobylka structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT hannosjuts structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT attiliovvargiu structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT giulianomalloci structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT julianreitz structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT anjaseybert structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT achilleassfrangakis structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms AT klaasmpos structuralandfunctionalanalysisofthepromiscuousacrbandadebeffluxpumpssuggestsdifferentdrugbindingmechanisms
_version_	1718407874571403264

Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms

Ejemplares similares