Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
Abstract Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) bo...
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Nature Portfolio
2021
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oai:doaj.org-article:0fa4073057894bb298076894588d4e7e2021-12-02T13:30:22ZChildren’s erythrocyte fatty acids are associated with the risk of islet autoimmunity10.1038/s41598-021-82200-92045-2322https://doaj.org/article/0fa4073057894bb298076894588d4e7e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82200-9https://doaj.org/toc/2045-2322Abstract Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case–control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n − 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n − 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.Sari NiinistöIris ErlundHye-Seung LeeUlla UusitaloIrma SalminenCarin Andrén AronssonHemang M. ParikhXiang LiuSandra HummelJorma ToppariJin-Xiong SheÅke LernmarkAnnette G. ZieglerMarian RewersBeena AkolkarJeffrey P. KrischerDavid GalasSiba DasNikita SakhanenkoStephen S. RichWilliam HagopianJill M. NorrisSuvi M. Virtanenthe TEDDY Study GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Sari Niinistö Iris Erlund Hye-Seung Lee Ulla Uusitalo Irma Salminen Carin Andrén Aronsson Hemang M. Parikh Xiang Liu Sandra Hummel Jorma Toppari Jin-Xiong She Åke Lernmark Annette G. Ziegler Marian Rewers Beena Akolkar Jeffrey P. Krischer David Galas Siba Das Nikita Sakhanenko Stephen S. Rich William Hagopian Jill M. Norris Suvi M. Virtanen the TEDDY Study Group Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity |
| description |
Abstract Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case–control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n − 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n − 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity. |
| format |
article |
| author |
Sari Niinistö Iris Erlund Hye-Seung Lee Ulla Uusitalo Irma Salminen Carin Andrén Aronsson Hemang M. Parikh Xiang Liu Sandra Hummel Jorma Toppari Jin-Xiong She Åke Lernmark Annette G. Ziegler Marian Rewers Beena Akolkar Jeffrey P. Krischer David Galas Siba Das Nikita Sakhanenko Stephen S. Rich William Hagopian Jill M. Norris Suvi M. Virtanen the TEDDY Study Group |
| author_facet |
Sari Niinistö Iris Erlund Hye-Seung Lee Ulla Uusitalo Irma Salminen Carin Andrén Aronsson Hemang M. Parikh Xiang Liu Sandra Hummel Jorma Toppari Jin-Xiong She Åke Lernmark Annette G. Ziegler Marian Rewers Beena Akolkar Jeffrey P. Krischer David Galas Siba Das Nikita Sakhanenko Stephen S. Rich William Hagopian Jill M. Norris Suvi M. Virtanen the TEDDY Study Group |
| author_sort |
Sari Niinistö |
| title |
Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity |
| title_short |
Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity |
| title_full |
Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity |
| title_fullStr |
Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity |
| title_full_unstemmed |
Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity |
| title_sort |
children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/0fa4073057894bb298076894588d4e7e |
| work_keys_str_mv |
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